Evidence map›Paper›PMID 37188245›Full record

ArticleNeurology. Clinical practice2023

Neurobrucellosis Mimicking Primary CNS Vasculitis-Should We Perform CSF Metagenomics Before Brain Biopsy?: A Case Report.

Marina Barrionuevo Mathias, Fernando Gatti Menezes, Gustavo Bruniera Peres Fernandes, Vitor Ribeiro Paes, Gisele Sampaio Silva, Pedro Braga-Neto, Alcino Alves Barbosa, Augusto César Penalva De Oliveira, Carlos Eduardo Baccin, Lívia Almeida Dutra

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Marina Barrionuevo MathiasHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Fernando Gatti MenezesHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Gustavo Bruniera Peres FernandesHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Vitor Ribeiro PaesHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Gisele Sampaio SilvaHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Pedro Braga-NetoHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Alcino Alves BarbosaHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Augusto César Penalva De OliveiraHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Carlos Eduardo BaccinHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Lívia Almeida DutraHospital Israelita Albert Einstein (MBM, FGM, GBPF, VRP, GSS, AAB, ACPDO, CEB, LAD), São Paulo; Department of Neurology and Neurosurgery (GSS), Universidade Federal de São Paulo, UNIFESP; Neurology Section (PB-N), Department of Clinical Medicine, Faculty of Medicine; and Center of Health Sciences (PB-N), Universidade Estadual Do Ceará, Fortaleza, Brazil.
Universidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To report a patient with neurobrucellosis mimicking primary CNS vasculitis (PCNSV) diagnosed by CSF metagenomic next-generation sequencing (mNGS). Methods: A 32-year-old male patient with a prior stroke developed headache, dizziness, fever, and memory complaints in the past 30 days. Physical examination was unremarkable except for slight apathy. He was investigated with brain MRI, cerebral digital angiography, CSF analysis with mNGS, and brain biopsy. Results: An examination of the brain MRI showed a left nucleocapsular gliosis compatible with prior stroke; MR angiogram showed circular enhancement of distal branches of the middle cerebral arteries. Digital angiogram revealed stenosis of intracranial carotid arteries and the left middle cerebral artery. The CSF disclosed 42 cells/mm Discussion: Brucellosis is an endemic disease in developing countries and may mimic PCNSV. Our patient fulfilled the criteria for possible PCNSV; however, brain biopsy was inconsistent with PCNSV, and CSF mNGS disclosed neurobrucellosis. This case illustrates the importance of CSF mNGS in the differential diagnosis of CNS vasculitis.

Identifiers

PMID37188245
PMCPMC10173873
OpenAlexW4376108347

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.