ArticleNuclear medicine and molecular imaging2023
Dual-Tracer Parathyroid Imaging Using Joint SPECT Reconstruction.
Article in Nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Purpose: We assessed the lesion detection performance of the dual-tracer parathyroid SPECT imaging using the joint reconstruction method. Materials and Methods: Thirty-six noise realizations were created from SPECT projections collected from an in-house neck phantom to emulate Results: In the phantom study, both the joint-AltInt method and the joint method improved SNR compared to the subtraction method at their optimal iteration by 444% and 81%, respectively. In the patient study, the joint-AltInt method yielded the highest AUC of 0.73 as compared with 0.72, 0.71, and 0.64 from the joint method, the subtraction method at optimal iteration, and the subtraction method at four iterations. At a specificity of at least 0.70, the joint-AltInt method yielded significantly higher sensitivity than the other methods (0.60 vs 0.46, 042, and 0.42; Conclusions: The joint reconstruction method yielded higher lesion detectability than the conventional method and holds promise for dual-tracer parathyroid SPECT imaging.
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