SynthesisAdvances in nutrition (Bethesda, Md.)2023
Artificially Sweetened Beverages and Health Outcomes: An Umbrella Review.
Synthesis in Advances in nutrition (Bethesda, Md.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Metabolic Dysfunction and Related Dietary Exposures in Relation to Pancreatic Cancer Risk: A Review of the Evidence.International journal of molecular sciences · 2026Pooled it
- Differential associations of beverage consumption with diabetic retinopathy: a systematic review and dose-response meta-analysis of observational studies.Frontiers in medicine · 2026Pooled it
- Sweetened beverages and cardiovascular outcomes: an umbrella review of mortality and health outcomes.Nutrition journal · 2025Pooled it
- Non-Sugar-Sweetened Beverages and Risk of Chronic Diseases: An Umbrella Review of Meta-analyses of Prospective Cohort Studies.Nutrition reviews · 2025Pooled it
- Research on the association between beverages consumption and cancer.Frontiers in medicine · 2025Pooled it
- The intersection of colorectal cancer and cardiovascular disease: shared mechanisms and clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Sugar sweetened and artificially sweetened beverages, fruit and vegetable juices and cancer risk: a World Cancer Research Fund International Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis.medRxiv : the preprint server for health sciences · 2026Article
- Low- and no-calorie sweeteners and beverages and their associated health outcomes: an umbrella review of systematic reviews and meta-analyses.Nutrition research and practice · 2026Review
- Association of Sweetened Beverages with Risk of Osteoporosis and First Fractures: Evidence from the United Kingdom Biobank.Calcified tissue international · 2026Article
- Sugar- and artificially sweetened beverages consumption, body weight, and eating disorders symptoms: findings from a Danish cohort from childhood to early adulthood.European journal of nutrition · 2026Article
- Artificial Sweeteners Induce Bacterial Drug Resistance and Modulate Gene Expression.Infection and drug resistance · 2026Article
- Effect of Replacing Added Sugars with Sucralose on Gut Microbiome Composition Among Asian Indian Adults in Two 12-week Randomized Controlled Trials.Current developments in nutrition · 2025Article
- Nutritional and Energy Profile of "No Added Sugar" Products Versus Their Conventional Counterparts on the Polish Food Market.Nutrients · 2025Article
- Ultra-processed foods, biological ageing, and all-cause mortality risk: a prospective cohort study using 172,225 participants from UK Biobank.GeroScience · 2025Article
- Association of unsweetened and sweetened tea consumption with risk of incident cardiovascular disease: Evidence from the UK Biobank.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Sweetened beverage intake and incident gastroesophageal reflux disease in a prospective cohort study.European journal of nutrition · 2025Article
- Yoga and chronic diseases: an umbrella review of systematic reviews and meta-analyses.Medical review (2021) · 2025Review
- Urinary excretion of low- and no-calorie sweeteners (LNCS) and associated food sources, as observed in the German cross-sectional KarMeN-study.European journal of nutrition · 2025Article
- Advertisements of ultra-processed products outside food outlets: field evidence from Montevideo, Uruguay.Public health nutrition · 2025Article
- Consumption of non-sugar sweeteners by Brazilian adolescents and adults in 2017-2018: Socioeconomic distribution and food sources.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The consumption of artificially sweetened beverages (ASBs) is increasing in some countries. However, some meta-analyses have found that habitual consumers of ASBs (compared with low or no consumption) had an increased risk on some health outcomes. We performed an umbrella review of meta-analyses to grade the credibility of the evidence of claimed observational associations between ASBs and health outcomes. Data were searched in Web of Science, Embase, and PubMed for systematic reviews published up to 25 May 2022, examining association between ASBs and any health outcomes. Certainty of the evidence for each health outcome was obtained based on statistical results of tests used in umbrella reviews. The AMSTAR-2 tool (16 items) was used to identify high-quality systematic reviews. Answers of each item were rated as yes, no, or partial yes (for a partial adherence to the standard). We included data from 11 meta-analyses with unique population, exposure, comparison group, outcome obtained from 7 systematic reviews (51 cohort studies and 4 case-control studies). ASBs were associated with higher risk of obesity, type 2 diabetes, all-cause mortality, hypertension, and cardiovascular disease incidence (supported by highly suggestive evidence). Evidence for other outcomes (colorectal cancer, pancreatic cancer, gastrointestinal cancer, cancer mortality, cardiovascular mortality, chronic kidney disease, coronary artery disease, and stroke) was weak. Results of the quality assessment of systematic reviews using AMSTAR-2 showed some notable deficiencies: unclear sources of funding of eligible studies and lack of predefined study protocols to guide authors. The consumption of ASBs was associated with a higher risk of obesity, type 2 diabetes, all-cause mortality, hypertension, and cardiovascular disease incidence. However, further cohort studies and clinical trials in humans are still needed to understand the impact of ASBs on health outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.