ArticleJournal of genetics and genomics = Yi chuan xue bao2023
Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling.
Article in Journal of genetics and genomics = Yi chuan xue bao, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 32 citations in OpenAlex.
- Nitric oxide-centred signaling networks in plants: from growth to postharvest.Frontiers in plant science · 2026Review
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- Nitric Oxide Regulates Multiple Signal Pathways in Plants via ProteinCurrent issues in molecular biology · 2025Review
- Morphophysiological and transcriptomic analyses during the development of microspores and megaspores inFrontiers in plant science · 2025Article
- Phosphorylation of auxin signaling repressor IAA8 by heat-responsive MPKs causes defective flower development.Plant physiology · 2024Article
- Auxin and abiotic stress responses.Journal of experimental botany · 2023Review
- SOURSOP: A Python Package for the Analysis of Simulations of Intrinsically Disordered Proteins.Journal of chemical theory and computation · 2023Article
- Unresolved roles of Aux/IAA proteins in auxin responses.Physiologia plantarumReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) family of transcriptional repressors. Notably, many auxin-modulated physiological processes are also regulated by nitric oxide (NO) that executes its biological effects predominantly through protein S-nitrosylation at specific cysteine residues. However, little is known about the molecular mechanisms in regulating the interactive NO and auxin networks. Here, we show that NO represses auxin signaling by inhibiting IAA17 protein degradation. NO induces the S-nitrosylation of Cys-70 located in the intrinsically disordered region of IAA17, which inhibits the TIR1-IAA17 interaction and consequently the proteasomal degradation of IAA17. The accumulation of a higher level of IAA17 attenuates auxin response. Moreover, an IAA17
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.