ArticleNeuroImage2023
Associations between age, sex, APOE genotype, and regional vascular physiology in typically aging adults.
Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Arterial Spin Labeling Hemodynamic Indices Relate to Cognitive and Small Vessel Disease Trajectories Over 11 Years.Stroke · 2026Article
- Repeatability of diffusion-weighted arterial spin labeling MRI for mapping blood-brain barrier water exchange rate at different postlabel delays.Magnetic resonance in medicine · 2026Article
- The differential relationship between white matter cerebrovascular perfusion and microstructure between normal cognition and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Hippocampal subfields in aging: Sex-specific trajectories in structure and hemodynamics.NeuroImage · 2025Article
- Sex differences in age-associated neurological diseases-A roadmap for reliable and high-yield research.Science advances · 2025Review
- Multi-cohort, multi-sequence harmonisation for cerebrovascular brain age.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Venous arterial spin labeling MRI signal is associated with oxygen supply-independent reduction in cerebral oxygen extraction in typically aging older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- MRI Assessment of Cerebral White Matter Microvascular Hemodynamics Across the Adult Lifespan.Journal of magnetic resonance imaging : JMRI · 2024Article
- Article
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Authors and funding
11 authors.
Funding
Abstract
Altered blood flow in the human brain is characteristic of typical aging. However, numerous factors contribute to inter-individual variation in patterns of blood flow throughout the lifespan. To better understand the mechanisms behind such variation, we studied how sex and APOE genotype, a primary genetic risk factor for Alzheimer's disease (AD), influence associations between age and brain perfusion measures. We conducted a cross-sectional study of 562 participants from the Human Connectome Project - Aging (36 to >90 years of age). We found widespread associations between age and vascular parameters, where increasing age was associated with regional decreases in cerebral blood flow (CBF) and increases in arterial transit time (ATT). When grouped by sex and APOE genotype, interactions between group and age demonstrated that females had relatively greater CBF and lower ATT compared to males. Females carrying the APOEε4 allele showed the strongest association between CBF decline and ATT incline with age. This demonstrates that sex and genetic risk for AD modulate age-associated patterns of cerebral perfusion measures.
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Registered trials
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