Evidence map›Paper›PMID 37187222›Full record

ReviewClinica chimica acta; international journal of clinical chemistry2023

Immunology of SARS-CoV-2 infection and vaccination.

Baoxu Lin, Linlin Cheng, Jin Zhang, Mei Yang, Yixiao Zhang, Jianhua Liu, Xiaosong Qin

Abstract readReview
In one paragraph

Review in Clinica chimica acta; international journal of clinical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Baoxu LinDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China; Liaoning Clinical Research Center for Laboratory Medicine, Shenyang 110004, China. Electronic address: 2645079122@qq.com.
Linlin ChengDepartment of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China. Electronic address: liliacheng@126.com.
Jin ZhangDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China; Liaoning Clinical Research Center for Laboratory Medicine, Shenyang 110004, China. Electronic address: zhangj6@sj-hospital.org.
Mei YangDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China; Liaoning Clinical Research Center for Laboratory Medicine, Shenyang 110004, China. Electronic address: 1285175459@qq.com.
Yixiao ZhangDepartment of Urology Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China. Electronic address: zhangyx201@hotmail.com.
Jianhua LiuDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China; Liaoning Clinical Research Center for Laboratory Medicine, Shenyang 110004, China. Electronic address: liujh@sj-hospital.org.
Xiaosong QinDepartment of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China; Liaoning Clinical Research Center for Laboratory Medicine, Shenyang 110004, China. Electronic address: qinxs@sj-hospital.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comprehensive elucidation of humoral immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination is critical for understanding coronavirus disease 2019 (COVID-19) pathogenesis in general and developing antibody-based diagnostic and therapeutic strategies specifically. Following the emergence of SARS-CoV-2, significant scientific research has been conducted worldwide using omics, sequencing and immunologic approaches. These studies have been critical to the successful development of vaccines. Here, the current understanding of SARS-CoV-2 immunogenic epitopes, humoral immunity to SARS-CoV-2 structural proteins and non-structural proteins, SARS-CoV-2-specific antibodies, and T-cell responses in convalescents and vaccinated individuals are reviewed. Additionally, we explore the integrated analysis of proteomic and metabolomic data to examine mechanisms of organ injury and identify potential biomarkers. Insight into the immunologic diagnosis of COVID-19 and improvements of laboratory methods are highlighted.

Indexed as

COVID-19Antibodies, ViralHumansImmunity, HumoralProteomicsSARS-CoV-2VaccinationAntibodies, ViralImmunologyMetabolomicsProteomicsSARS-CoV-2Vaccine

Identifiers

PMID37187222
PMCPMC10182659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.