ArticleJournal of critical care2023
Effects of correction rate for severe hyponatremia in the intensive care unit on patient outcomes.
Article in Journal of critical care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06675591 (Mortality and Neurologic Complications Associated With Rapid Versus Slow Correction of Hyponatremia), which is not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mortality and Neurologic Complications Associated With Rapid Versus Slow Correction of Hyponatremia
Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- On the optimal sodium correction rate in hyponatraemia and clinical outcome: a meta-analysis.Emergency medicine journal : EMJ · 2026Pooled it
- Outcomes with Sodium Overcorrection in Chronic Hyponatremia: A Systematic Review and Meta-analysis.Journal of general internal medicine · 2026Pooled it
- Key predictors of mortality in profound hyponatremia beyond the correction rate.Clinical kidney journal · 2026Article
- Hydroelectrolytic syndromes in neuroanesthesia and neurocritical care.World journal of critical care medicine · 2025Review
- Impact of Nephrology Consultation on Moderate and Severe Hyponatremia Outcomes and Length of Hospital Stay.Cureus · 2025Article
- Intensive Care Management of Severe Hyponatraemia-An Observational Study.Medicina (Kaunas, Lithuania) · 2024Observational
- Osmotic Demyelination Syndrome Associated with Uremia and Elevated Serum Osmolality.Neurocritical care · 2024Article
- [Consensus recommendations on the diagnosis and treatment of hyponatremia from the Austrian Society for Nephrology 2024].Wiener klinische Wochenschrift · 2024Article
- Case report: Acute severe hyponatremia-induced seizures in a newborn: a community-acquired case and literature review.Frontiers in pharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeLimited evidence exists regarding outcomes associated with different correction rates of severe hyponatremia. MATERIALS AND
methodsThis retrospective cohort analysis employed a multi-center ICU database to identify patients with sodium ≤120 mEq/L during ICU admission. We determined correction rates over the first 24 h and categorized them as rapid (> 8 mEq/L/day) or slow (≤ 8 mEq/L/day). The primary outcome was in-hospital mortality. Secondary outcomes included hospital-free days, ICU-free days, and neurological complications. We used inverse probability weighting for confounder adjustment.
resultsOur cohort included 1024 patients; 451 rapid and 573 slow correctors. Rapid correction was associated with lower in-hospital mortality (absolute difference: -4.37%; 95% CI, -8.47 to -0.26%), longer hospital-free days (1.80 days; 95% CI, 0.82 to 2.79 days), and longer ICU-free days (1.16 days; 95% CI, 0.15 to 2.17 days). There was no significant difference in neurological complications (2.31%; 95% CI, -0.77 to 5.40%).
conclusionRapid correction (>8 mEq/L/day) of severe hyponatremia within the first 24 h was associated with lower in-hospital mortality and longer ICU and hospital-free days without an increase in neurological complication. Despite major limitations, including the inability to identify the chronicity of hyponatremia, the results have important implications and warrant prospective studies.
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Registered trials
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