ArticleJournal of the American Chemical Society2023
Radical Hydrocarboxylation of Unactivated Alkenes via Photocatalytic Formate Activation.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 104 citations in OpenAlex.
- Light-Driven Epimerization: Diastereoconvergent Synthesis of [Angewandte Chemie (International ed. in English) · 2026Article
- Photocatalytic, Scalable Anti-Markovnikov Hydrocarboxylation of Unactivated Alkenes via Amine-Mediated COJACS Au · 2026Article
- Photocatalytic reductive carboxylation of unactivated hydrazones with CONature communications · 2026Article
- Article
- Illuminating Synergistic Catalysis: SET-HAT Unlocks Proximal C-H Arylation of Aromatic Amines.JACS Au · 2026Article
- Harnessing COJournal of the American Chemical Society · 2026Article
- Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion.Nature synthesis · 2026Article
- Proximal and Remote Hydrocarboxylation of Alkenes with Carbon Dioxide Enabled by Nickel-Catalyzed Hydrogen Atom Transfer.Angewandte Chemie (International ed. in English) · 2025Article
- Photocatalytic 1,3-difluoroalkylcarboxylation of alkenes by triple kinetic-controlled radical self-ordering.Chemical science · 2025Article
- Photo-induced ring-maintaining hydrosilylation of unactivated alkenes with hydrosilacyclobutanes.Nature communications · 2025Article
- Visible-Light-Driven Carboxylative 1,2-Difunctionalization of C=C Bonds with Tetrabutylammonium Oxalate.ACS central science · 2025Article
- C(spACS catalysis · 2025Article
- Photocatalytic deuterocarboxylation of alkynes with oxalate.Chemical science · 2024Article
- Nickel-Catalyzed Hydrocarboxylation of Terminal Unactivated Alkenes: Formation of Branched Carboxylic Acids and Competing Catalyst Deactivation from COOrganometallics · 2024Article
- Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation.Organic letters · 2024Article
- Photochemical dearomative skeletal modifications of heteroaromatics.Chemical Society reviews · 2024Review
- Visible-light-driven alkene dicarboxylation with formate and COChemical science · 2024Article
- γ-Butyrolactone Synthesis from Allylic Alcohols Using the COPrecision chemistry · 2024Article
- Single electron reduction of NHC-COChemical science · 2024Article
- Recent Advances in C-H Functionalisation through Indirect Hydrogen Atom Transfer.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Herein we disclose a strategy to promote the hydrocarboxylation of unactivated alkenes using photochemical activation of formate salts. We illustrate that an alternative initiation mechanism circumvents the limitations of prior approaches and enables hydrocarboxylation of this challenging substrate class. Specifically, we found that accessing the requisite thiyl radical initiator without an exogenous chromophore eliminates major byproducts that have plagued attempts to exploit similar reactivity for unactivated alkene substrates. This redox-neutral method is technically simple to execute and effective across a broad range of alkene substrates. Feedstock alkenes, such as ethylene, are hydrocarboxylated at ambient temperature and pressure. A series of radical cyclization experiments indicate how the reactivity described in this report can be diverted by more complex radical processes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.