Evidence map›Paper›PMID 37186855›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Contraception ends the genetic maintenance of human same-sex sexual behavior.

Siliang Song, Jianzhi Zhang

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Siliang SongDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-4658-5062
Jianzhi ZhangDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0001-6141-1290
University of Michigan · US

Funding

Genomic and Systemic Approaches to Evolutionary MechanismsR35GM139484 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JIANZHI ZHANG · 2021 to 2026
$3.2M
High-Performance Computing Cluster for Biomedical ResearchS10OD026825 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ATHEY, BRIAN DAVID · 2020 to 2020
$600k
NIGMS NIH HHS R35 GM139484NIH HHS S10 OD026825
6 · The paper itself

Abstract

Because human same-sex sexual behavior (SSB) is heritable and leads to fewer offspring, it is puzzling why SSB-associated alleles have not been selectively purged. Current evidence supports the antagonistic pleiotropy hypothesis that SSB-associated alleles benefit individuals exclusively performing opposite-sex sexual behavior by increasing their number of sexual partners and consequently their number of offspring. However, by analyzing the UK Biobank, here, we show that having more sexual partners no longer predicts more offspring since the availability of oral contraceptives in the 1960s and that SSB is now genetically negatively correlated with the number of offspring, suggesting a loss of SSB's genetic maintenance in modern societies.

Indexed as

ContraceptionSexual BehaviorAllelesHumansSexual Partnersantagonistic pleiotropygenetic correlationhomosexualityreproductionselection

Identifiers

PMID37186855
PMCPMC10214190
OpenAlexW4376641918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.