ArticleProceedings of the National Academy of Sciences of the United States of America2023
A self-inactivating invertebrate opsin optically drives biased signaling toward Gβγ-dependent ion channel modulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Light-modulated stem cells in the camera-type eye of an annelid model for adult brain plasticity.Nature communications · 2025Article
- Molecular basis underlying the specificity of an antagonist AA92593 for mammalian melanopsins.The Journal of biological chemistry · 2025Article
- Optogenetic engineering for ion channel modulation.Current opinion in chemical biology · 2025Review
- A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits.Nature methods · 2024Article
- A bistable inhibitory OptoGPCR for multiplexed optogenetic control of neural circuits.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
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Abstract
Animal opsins, light-sensitive G protein-coupled receptors, have been used for optogenetic tools to control G protein-dependent signaling pathways. Upon G protein activation, the Gα and Gβγ subunits drive different intracellular signaling pathways, leading to complex cellular responses. For some purposes, Gα- and Gβγ-dependent signaling needs to be separately modulated, but these responses are simultaneously evoked due to the 1:1 stoichiometry of Gα and Gβγ Nevertheless, we show temporal activation of G protein using a self-inactivating invertebrate opsin,
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