Evidence map›Paper›PMID 37186472›Full record

ArticleCancer science2023

Senescent CD8

Toshio Kakuda, Junpei Suzuki, Yuko Matsuoka, Tadahiko Kikugawa, Takashi Saika, Masakatsu Yamashita

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. BNT162b2 COVID-19 vaccination elicits the expansion of CD16The Journal of allergy and clinical immunology · 2025
    Article
  8. Review
  9. Review
  10. Senescent T Cells: The Silent Culprit in Acute Myeloid Leukemia Progression?International journal of molecular sciences · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Senescent CD8Cancer science · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Toshio KakudaDepartment of Urologye, Graduate School of Medicin, Ehime University, Toon, Japan.
Junpei SuzukiDepartment of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan.
Yuko MatsuokaTranslational Research Center, Ehime University Hospital, Ehime University, Toon, Japan.
Tadahiko KikugawaDepartment of Urologye, Graduate School of Medicin, Ehime University, Toon, Japan.
Takashi SaikaDepartment of Urologye, Graduate School of Medicin, Ehime University, Toon, Japan.
Masakatsu YamashitaDepartment of Immunology, Graduate School of Medicine, Ehime University, Toon, Japan.ORCID https://orcid.org/0000-0002-8975-3513
Ehime University · JPEhime University Hospital · JP

Funding

Japan Society for the Promotion of Science 20H03504Japan Society for the Promotion of Science 22K07121Japan Society for the Promotion of Science 22K15609
6 · The paper itself

Abstract

It has been suggested that aging of the immune system (immunosenescence) results in a decline in the acquired immune response, which is associated with an increase in age-related tumorigenesis. T-cell senescence plays a critical role in immunosenescence and is involved in the age-related decline of the immune function, which increases susceptibility to certain cancers. However, it has been shown that CD8

Indexed as

CD8-Positive T-LymphocytesMelanoma, ExperimentalAdaptive ImmunityAgingAnimalsKiller Cells, NaturalMiceantigen-independent cytotoxicityimmunosenescenceMeninsenescent CD8+ T cellsT-cell innate functions

Identifiers

PMID37186472
PMCPMC10323091
OpenAlexW4367053793

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.