ArticleAdvanced materials (Deerfield Beach, Fla.)2023
Metasurface-Enhanced Mid-Infrared Spectrochemical Imaging of Tissues.
Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Fix or freeze? Spectral differences arising from tissue preparation in chemical imaging.The Analyst · 2026Article
- Dynamically tunable membrane metasurfaces for infrared spectroscopy and strong light-matter interactions.Light, science & applications · 2026Article
- Intelligent Stain-Free Histology on Structural Colorimetric Nanocavities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fix or Freeze? Spectral Differences Arising from Tissue Preparation in Chemical Imaging.bioRxiv : the preprint server for biology · 2025Article
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
- Combining quantum cascade lasers and plasmonic metasurfaces to monitorNanophotonics (Berlin, Germany) · 2025Article
- Mass-Manufactured Gradient Plasmonic Metasurfaces for Enhanced Mid-IR Spectrochemical Analysis of Complex Biofluids.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- High-Precision Biochemical Sensing with Resonant Monocrystalline Plasmonic Ag Microcubes in the Mid-Infrared Spectrum.ACS nano · 2025Article
- Broadband perfect Littrow diffraction metasurface under large-angle incidence.Nanophotonics (Berlin, Germany) · 2025Article
- Leveraging Optical Anisotropy of the Morpho Butterfly Wing for Quantitative, Stain-Free, and Contact-Free Assessment of Biological Tissue Microstructures.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Nanostructured Surfaces with Plasmonic Activity and Superhydrophobicity: Review of Fabrication Strategies and Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Fibroblast-Adipocyte Lineage Cell Interactions Result in Differential Production of Extracellular Matrix Proteins.Cellular and molecular bioengineering · 2024Article
- High-throughput antibody screening with high-quality factor nanophotonics and bioprinting.ArXiv · 2024Article
- Thermal imaging through hot emissive windows.Communications engineering · 2024Article
- Machine learning-assisted mid-infrared spectrochemical fibrillar collagen imaging in clinical tissues.Journal of biomedical optics · 2024Article
- The rise of electrically tunable metasurfaces.Science advances · 2024Review
- To label or not: the need for validation in label-free imaging.Journal of biomedical optics · 2024Review
- Surface plasmons-phonons for mid-infrared hyperspectral imaging.Science advances · 2024Article
- Machine learning assisted mid-infrared spectrochemical fibrillar collagen imaging in clinical tissues.bioRxiv : the preprint server for biology · 2024Article
- Dynamic construction of refractive index-dependent vibrations using surface plasmon-phonon polaritons.Nature communications · 2023Article
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Abstract
Label-free and nondestructive mid-infrared vibrational hyperspectral imaging is an essential tissue analysis tool, providing spatially resolved biochemical information critical to understanding physiological and pathological processes. However, the chemically complex and spatially heterogeneous composition of tissue specimens and the inherently weak interaction of infrared light with biomolecules limit the analytical performance of infrared absorption spectroscopy. Here, an advanced mid-infrared spectrochemical tissue imaging modality is introduced using metasurfaces that support strong surface-localized electromagnetic fields to capture quantitative molecular maps of large-area murine brain tissue sections. The approach leverages polarization-multiplexed multi-resonance plasmonic metasurfaces to simultaneously detect various functional biomolecules. The surface-enhanced mid-infrared spectral imaging method eliminates the non-specific effects of bulk tissue morphology on quantitative spectral analysis and improves chemical selectivity. This study shows that metasurface enhancement increases the retrieval of amide I and II bands associated with protein secondary structures. Moreover, it is demonstrated that plasmonic metasurfaces enhance the chemical contrast in infrared images and enable detection of ultrathin tissue regions that are not otherwise visible to conventional mid-infrared spectral imaging. While this work uses murine brain tissue sections, the chemical imaging method is well-suited for other tissue types, which broadens its potential impact for translational research and clinical histopathology.
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