Evidence map›Paper›PMID 37186316›Full record

ArticlePaediatric and perinatal epidemiology2023

Risks of adverse perinatal outcomes in relation to maternal depressive symptoms: A prospective cohort study in Kenya.

Anna Larsen, Jillian Pintye, Felix Abuna, Amritha Bhat, Julia C Dettinger, Laurén Gomez, Mary M Marwa, Nancy Ngumbau, Ben Odhiambo, Amanda I Phipps and 5 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Paediatric and perinatal epidemiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03070600 (Delivering PrEP in Pregnancy), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03070600 phase4completednot on this map

Delivering PrEP in Pregnancy

TypeinterventionalSponsorUniversity of WashingtonRan2018 to 2021Enrolled4,447ConditionsHIV Infections, Pregnancy RelatedArmsUniversal PrEP Counseling, Targeted PrEP Counseling
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Anna LarsenDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-0096-9386
Jillian PintyeDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Felix AbunaThe University of Nairobi, Nairobi, Kenya.
Amritha BhatDepartment of Psychiatry and Behavioral Services, School of Medicine, University of Washington, Seattle, Washington, USA.
Julia C DettingerDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Laurén GomezDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Mary M MarwaThe University of Nairobi, Nairobi, Kenya.
Nancy NgumbauDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Ben OdhiamboThe University of Nairobi, Nairobi, Kenya.
Amanda I PhippsDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Barbra A RichardsonDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Salphine WatoyiThe University of Nairobi, Nairobi, Kenya.
Joshua SternDepartment of Global Health, University of Washington, Seattle, Washington, USA.
John KinuthiaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Grace John-StewartDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
University of Washington · USUniversity of Nairobi · KEKenyatta National Hospital · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Delivering PrEP in PregnancyR01AI125498 · NIAID · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2016 to 2020
$3.6M
Evaluating Infant PrEP Exposure During Pregnancy and BreastfeedingR01HD100201 · NICHD · UNIVERSITY OF WASHINGTON · PI PINTYE, JILLIAN · 2019 to 2023
$3.4M
PrEP optimized for mothers (PrOM): efficient PrEP integration in MCH clinicsR01HD094630 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C., KOHLER, PAMELA · 2017 to 2021
$3.3M
Evaluating perinatal mood and anxiety disorder in Kenyan: a mixed methods approachF32HD108857 · NICHD · UNIVERSITY OF WASHINGTON · PI LARSEN, ANNA M · 2022 to 2023
$144k
Evaluating maternal depression among adolescent and adult women in KenyaF31HD101149 · NICHD · UNIVERSITY OF WASHINGTON · PI LARSEN, ANNA M · 2019 to 2022
$125k
NIAID NIH HHS P30 AI027757NIAID NIH HHS R01 AI125498NICHD NIH HHS F31 HD101149NICHD NIH HHS F32 HD108857NICHD NIH HHS R01 HD094630NICHD NIH HHS R01 HD100201
6 · The paper itself

Abstract

backgroundEvidence gaps remain regarding the influence of prenatal psychosocial factors on adverse pregnancy outcomes.

objectiveThe objective of this study is to evaluate relationships between psychosocial factors and adverse perinatal outcomes among Kenyan women.

methodsWe analysed data from a prospective cohort study enrolling HIV-negative women in pregnancy (NCT03070600) in 20 antenatal clinics in Western Kenya. Study nurses assessed depressive symptoms using the Center for Epidemiologic Studies Depression Scale (CESD-10), social support using the Medical Outcomes Survey scale (MOS-SSS), intimate partner violence (IPV) with the Hurt, Insult, Threaten, Scream scale (HITS), and pregnancy outcomes at 6 weeks postpartum. Cox proportional hazards models were used to evaluate relationships between depressive symptoms (moderate-to-severe [MSD, CESD-10 ≥10] and mild-to-severe [Mild-SD, CESD-10 ≥5]), low social support (MOS-SSS <72), and IPV (HITS ≥10) with adverse perinatal outcomes of pregnancy loss, stillbirth, preterm birth (PTB), small for gestational age, and neonatal mortality. We also estimated the population attributable risk.

resultsAmong 4153 women, 23.9% (n = 994) had MSD, 54.7% (n = 2273) mild-SD, 37.3% (n = 1550) low social support, and 7.8% (n = 323) experienced IPV. Pregnancy loss was 5-fold higher among women with MSD (adjusted hazard ratio [HR] 5.04, 95% confidence interval [CI] 2.44, 10.42); 37.4% of losses were attributable to MSD. Mild-SD was associated with PTB (HR 1.39, 95% CI 1.03, 1.87). Stillbirth risk more than doubled among women reporting low social support (HR 2.37, 95% CI 1.14, 4.94).

conclusionsAdverse perinatal outcomes were common and associated with prenatal depressive symptoms and low social support in this large cohort of Kenyan mother-infant pairs.

Indexed as

Abortion, SpontaneousPremature BirthDepressionFemaleHumansInfantInfant, NewbornKenyaPregnancyProspective StudiesStillbirthdepressionKenyaperinatalpregnancy losspreterm birthsocial support

Identifiers

PMID37186316
PMCPMC10524238
OpenAlexW4367051376

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.