ArticleActa obstetricia et gynecologica Scandinavica2023
Twins vs singletons-Long-term health outcomes.
Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Prevention of preterm birth in twin-to-twin transfusion syndrome: a systematic review and network meta-analysis.Journal of perinatal medicine · 2024Pooled it
- Cohort Profile: The Tokyo Adolescent Mental Health Study (TAMHS).Journal of epidemiology · 2026Article
- Placental Abruption, Preterm Delivery, and Cardiovascular Disease in Twin Offspring.Journal of the American Heart Association · 2026Article
- Antipsychotic Discontinuation and Re-initiation in Pregnant Women With Schizophrenia: A Retrospective Cohort Study From South Korea.Schizophrenia bulletin · 2026Article
- Exploring the lived experiences of pregnant women regarding the challenges and needs of higher-order multiple pregnancies in Western Iran: a phenomenological descriptive study.BMC public health · 2025Article
- First- and Second-Trimester Uterine Artery Doppler and Hypertensive Disorders in Twin Pregnancies.Journal of clinical medicine · 2025Article
- Vaginal Deliveries Were as Safe as Cesarean Sections for the Long-Term Cardiovascular Health of Preterm Twins.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Amniocentesis and Risk of Fetal Loss in Dichorionic-Diamniotic Twin Pregnancy: A Case-Control Study.Prenatal diagnosis · 2025Observational
- First-trimester screening and small for gestational age in twin pregnancies: a single center cohort study.Archives of gynecology and obstetrics · 2025Article
- Placental abruption and perinatal mortality in twins: novel insight into management at preterm versus term gestations.European journal of epidemiology · 2024Article
- First-trimester serum biomarkers in twin pregnancies and adverse obstetric outcomes-a single center cohort study.Archives of gynecology and obstetrics · 2024Article
- Is the Early Screening of Lower Genital Tract Infections Useful in Preventing Adverse Obstetrical Outcomes in Twin Pregnancy?Journal of clinical medicine · 2024Article
- Abnormal cleavage up to Day 3 does not compromise live birth and neonatal outcomes of embryos that have achieved full blastulation: a retrospective cohort study.Human reproduction (Oxford, England) · 2024Article
- Higher obstetric and perinatal risks for twins and the need for single embryo transfers in assisted reproduction.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Twins vs singletons-Long-term health outcomes.Acta obstetricia et gynecologica Scandinavica · 2023Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMultiple gestations are a risk factor for most pregnancy complications. The current study aimed to study whether offspring born after twin pregnancies are at increased risk for long-term health complications. MATERIAL AND
methodsA retrospective cohort study was conducted in a large medical center, including all offspring born between the years 1991-2021, which were followed-up until 18 years of age. Hospital-based diagnoses of the offspring were categorized into main groups of morbidities: cardiac, respiratory, infectious, neurological, malignancy, and metabolic. Incidence of hospitalization with diagnoses from each main group was compared between twins and singletons, as well as time to first hospitalization. Cox proportional hazard models were used to study the association between twins vs singletons and hospitalizations by grouped morbidities, while adjusting for maternal age, ethnicity and gender, besides maternal recurrence in the cohort.
resultsA total of 369 478 offspring were included in the analysis; of these 11 986 (3.2%) were twins and 357 492 (96.8%) were singletons. Twins were more likely to be delivered preterm (odds ratio = 17.65, 95% CI: 16.74-18.60), by cesarean delivery and following infertility treatments. Incidence of hospitalizations with all morbidity groups was slightly, some significantly, higher among twins, including cardiac: 1.9% vs 1.5%, respiratory; 8.4% vs 7.1%, neurological: 7.7% vs 7.4%, infectious: 26.0% vs 24.1%, and malignancies: 0.7% vs 0.4%. The risk remained higher in the multivariable analyses (adjusted hazard ratios ranging between 1.09-1.75). When stratifying by gestational age at delivery, the risk for most morbidities was lower among twins vs singletons born in similar gestational ages.
conclusionsTwins as compared to singletons are at increased risk for most morbidities due to their risk of being born earlier.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.