Evidence map›Paper›PMID 37186083›Full record

ArticleApplied clinical informatics2023

Challenges of Integrating APOL1 Genetic Test Results into the Electronic Health Record.

Luke V Rasmussen, Akansha H Agrawal, Paul Botsford, Andrew Powers, Jeffrey Schnoebelen, Stavroula Xinos, Gail Harper, Jane Thanner, Sarah McCabe, Stephen Moore and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Applied clinical informatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Luke V RasmussenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Akansha H AgrawalDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Paul BotsfordInformation Services, Digital Solutions, Northwestern Medicine, Chicago, Illinois, United States.
Andrew PowersInformation Services, Clinical Applications, Northwestern Medicine, Chicago, Illinois, United States.
Jeffrey SchnoebelenInformation Services, Business Relationship Management, Northwestern Medicine, Chicago, Illinois, United States.
Stavroula XinosInformation Services, Digital Administration, Northwestern Medicine, Chicago, Illinois, United States.
Gail HarperBusiness Development and Strategic Outreach, Knight Diagnostic Laboratories, Oregon Health & Science University, Portland, Oregon, United States.
Jane ThannerInformation Technology Group, Oregon Health & Science University, Portland, Oregon, United States.
Sarah McCabeKnight Diagnostic Laboratories, Oregon Health & Science University, Portland, Oregon, United States.
Stephen MooreKnight Diagnostic Laboratories, Oregon Health & Science University, Portland, Oregon, United States.
Catherine A WicklundDepartment of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Debra DuquetteDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
Elisa J GordonDepartment of Surgery, Section of Surgical Sciences, and Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Northwestern Medicine · USNorthwestern University · USOregon Health & Science University · USVanderbilt University Medical Center · US

Funding

Integrating a culturally competent APOL1 genetic testing program into living donor evaluationR01DK128207 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AGRAWAL, AKANSHA, FRIEDEWALD, JOHN J · 2021 to 2025
$3.3M
NIDDK NIH HHS R01 DK128207
6 · The paper itself

Abstract

objectivesIntegrating genetic test results into the electronic health record (EHR) is essential for integrating genetic testing into clinical practice. This article describes the organizational challenges of integrating discrete apolipoprotein L1 (

methodsWe convened a multidisciplinary team across three institutions (Northwestern University, Northwestern Memorial HealthCare [NMHC], and OHSU Knight Diagnostic Laboratories [KDL]), including researchers, physicians, clinical information technology, and project management. Through a series of meetings over a year between the team and the genetic testing laboratory, we explored and adjusted our EHR integration plan based on regulatory and budgetary constraints.

resultsOur original proposal was to transmit results from KDL to NMHC as structured data sent via Health Level Seven (HL7) v2 message. This was ultimately deemed infeasible given the time and resources required to establish the interface, and the low number of samples to be processed for the study (

conclusionEven with early and ongoing stakeholder engagement, dedicated project management, and funding, unanticipated implementation challenges-especially for research projects-can result in drastic design tradeoffs.

Indexed as

Apolipoprotein L1Electronic Health RecordsData CollectionDelivery of Health CareGenetic TestingHumansAPOL1 protein, humanApolipoprotein L1

Identifiers

PMID37186083
PMCPMC10132929
OpenAlexW4367145860

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.