SynthesisMolecular psychiatry2023
A systematic review of neuroimaging epigenetic research: calling for an increased focus on development.
Synthesis in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood.Journal of child psychology and psychiatry, and allied disciplines · 2026Pooled it
- The Role of Hydrogen Sulfide (HInternational journal of molecular sciences · 2023Pooled it
- Brain-targeted epigenetic effects of two emerging psychoplastogens: ketamine & MDMA.Translational psychiatry · 2026Article
- An epigenetic framework for understanding contextual influences on neural and socio-emotional development: Narrative review and case-study of the oxytocin receptor.Developmental cognitive neuroscience · 2026Review
- Consortium profile: the methylation, imaging and NeuroDevelopment (MIND) consortium.Molecular psychiatry · 2026Review
- The Peripheral Epigenome Predicts White Matter Volume Contingent on Developmental Stage: An ECHO Study.Molecular neurobiology · 2025Article
- Review
- Epigenetic age across development in children and adolescents with ADHD.Psychiatry research · 2025Article
- Peripheral DNA Methylation of Cortisol- and Serotonin-Related Genes Predicts Hippocampal Volume in a Pediatric Population.Biological psychiatry global open science · 2025Article
- Biospecimens in the HEALthy Brain and Child Development (HBCD) Study: Rationale and protocol.Developmental cognitive neuroscience · 2024Article
- DNA methylation as a possible mechanism linking childhood adversity and health: results from a 2-sample mendelian randomization study.American journal of epidemiology · 2024Article
- DNA methylation at birth and lateral ventricular volume in childhood: a neuroimaging epigenetics study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- CBLL1 is hypomethylated and correlates with cortical thickness in transgender men before gender affirming hormone treatment.Scientific reports · 2023Article
- Elevated plasma BJournal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Epigenetic mechanisms, such as DNA methylation (DNAm), have gained increasing attention as potential biomarkers and mechanisms underlying risk for neurodevelopmental, psychiatric and other brain-based disorders. Yet, surprisingly little is known about the extent to which DNAm is linked to individual differences in the brain itself, and how these associations may unfold across development - a time of life when many of these disorders emerge. Here, we systematically review evidence from the nascent field of Neuroimaging Epigenetics, combining structural or functional neuroimaging measures with DNAm, and the extent to which the developmental period (birth to adolescence) is represented in these studies. We identified 111 articles published between 2011-2021, out of which only a minority (21%) included samples under 18 years of age. Most studies were cross-sectional (85%), employed a candidate-gene approach (67%), and examined DNAm-brain associations in the context of health and behavioral outcomes (75%). Nearly half incorporated genetic data, and a fourth investigated environmental influences. Overall, studies support a link between peripheral DNAm and brain imaging measures, but there is little consistency in specific findings and it remains unclear whether DNAm markers present a cause, correlate or consequence of brain alterations. Overall, there is large heterogeneity in sample characteristics, peripheral tissue and brain outcome examined as well as the methods used. Sample sizes were generally low to moderate (median n
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