ArticleEuropean journal of applied physiology2023
Enhanced skeletal muscle contractile function and corticospinal excitability precede strength and architectural adaptations during lower-limb resistance training.
Article in European journal of applied physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of strength training on neuromuscular adaptations in the development of maximal strength: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Non invasive techniques for direct muscle quality assessment after exercise intervention in older adults: a systematic review.BMC geriatrics · 2024Pooled it
- Multicomponent Online Intervention Improves Sarcopenia-Related Traits Following Long-Term Metabolic Bariatric Surgery: A Randomized Clinical Trial.Obesity surgery · 2026Trial
- Physical function and psychosocial outcomes after a 6-month self-paced aquatic exercise program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome.European journal of applied physiology · 2025Trial
- High-Intensity Exercise Performance as a Complex Adaptive System: An Integrative Review.Muscles (Basel, Switzerland) · 2026Review
- Context-Dependent Differences in Muscle Architecture Following Fatigue in Ultramarathon Athletes: A Comparison Between Laboratory and Real Race Settings.Diagnostics (Basel, Switzerland) · 2026Article
- Transient effects in corticospinal and reticulospinal tract excitability induced by motor skill and isometric resistance training.Brain research · 2026Article
- Relative Contributions of Motor Unit Firing Pattern, Muscle Quantity, and Muscle Quality to Maximum Muscle Strength in Female Patients with Early and Severe Knee Osteoarthritis.Annals of biomedical engineering · 2025Article
- Effects and mechanisms of resistance training on corticospinal adaptation.Frontiers in physiology · 2025Review
- Establishing reference values for tensiomyography-derived parameters in soccer players: insights from a systematic review, meta-analysis and meta-regression.Biology of sport · 2025Review
- The effects of an 8-week French Contrast Training program on lower limb strength and power in elite martial arts athletes.Frontiers in sports and active living · 2025Article
- Effects of 6 weeks of complex training on athletic performance and post-activation performance enhancement effect magnitude in soccer players: a cross-sectional randomized study.Biology of sport · 2025Article
- Cortical activation patterns mediating motor recovery: a randomized controlled fNIRS study of rTMS-integrated dual-task training in stroke survivors.Frontiers in neurologyArticle
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6 authors.
Funding
Abstract
purposeEvolving investigative techniques are providing greater understanding about the early neuromuscular responses to resistance training among novice exercisers. The aim of this study was to investigate the time-course of changes in muscle contractile mechanics, architecture, neuromuscular, and strength adaptation during the first 6-weeks of lower-limb resistance training.
methodsForty participants: 22 intervention (10 males/12 females; 173.48 ± 5.20 cm; 74.01 ± 13.13 kg) completed 6-week resistance training, and 18 control (10 males/8 females; 175.52 ± 7.64 cm; 70.92 ± 12.73 kg) performed no resistance training and maintained their habitual activity. Radial muscle displacement (Dm) assessed via tensiomyography, knee extension maximal voluntary contraction (MVC), voluntary activation (VA), corticospinal excitability and inhibition via transcranial magnetic stimulation, motor unit (MU) firing rate, and muscle thickness and pennation angle via ultrasonography were assessed before and after 2, 4, and 6-weeks of dynamic lower-limb resistance training or control.
resultsAfter 2-weeks training, Dm reduced by 19-25% in the intervention group; this was before any changes in neural or morphological measures. After 4-weeks training, MVC increased by 15% along with corticospinal excitability by 16%; however, there was no change in VA, corticospinal inhibition, or MU firing rate. After 6-weeks training there was further MVC increase by 6% along with muscle thickness by 13-16% and pennation angle by 13-14%.
conclusionEnhanced contractile properties and corticospinal excitability occurred before any muscle architecture, neural, and strength adaptation. Later increases in muscular strength can be accounted for by architectural adaptation.
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