ArticleJournal of veterinary internal medicine
Albuminuria and proteinuria in dogs infected with Dirofilaria repens: A cross-sectional study.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Clinico-pathological and renal morphological findings in dogs naturally infected with Dirofilaria repens.BMC veterinary research · 2026Article
- Establishment of a reference interval for urinary albumin-to-creatinine ratio in dogs.Veterinary clinical pathology · 2022Article
- Albuminuria and proteinuria in dogs infected with Dirofilaria repens: A cross-sectional study.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundIt is unknown whether Dirofilaria repens is capable of causing similar glomerular lesions, as does Dirofilaria immitis.
objectiveTo determine whether D. repens infection could cause albuminuria or proteinuria. ANIMALS: Sixty-five clinically healthy laboratory beagle dogs.
methodsIn this cross-sectional study, dogs were tested for D. repens infection (modified Knott test, PCR test, D. immitis antigen test) and were grouped as "D. repens infected" or "control" dogs. Urinary albumin-to-creatinine ratio (UAC) and urinary protein-to-creatinine ratio (UPC) were measured from samples taken by cystocentesis.
resultsForty-three (26 infected, 17 control) dogs were included in the final study group. UAC but not UPC level was significantly higher in the infected group (UAC median 12.5; range, 0-700 mg/g and UPC median 0.15; range, 0.06-1.06) than in the control group (UAC median 6.3; range, 0-28 mg/g and UPC median 0.13; range, 0.05-0.64; P = .02 and P = .65). Overt proteinuria (UPC > 0.5) was present in 6/26 (23%) of the infected dogs and 1/17 (6%) of the control dogs. Albuminuria (UAC > 19 mg/g) was detected in 9/26 (35%) dogs in the infected group, and 2/17 dogs (12%) in the control group. CONCLUSIONS AND CLINICAL IMPORTANCE: D. repens might cause similar glomerular lesions to those caused by D. immitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.