Evidence map›Paper›PMID 37185874›Full record

ArticleLife science alliance2023

SIRT6 overexpression in the nucleus protects mouse retinal pigment epithelium from oxidative stress.

Xue Yang, Jin-Yong Chung, Usha Rai, Noriko Esumi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. MiR-21-5p promotes RPE cell necroptosis by targeting Peli1 in a rat model of AMD.In vitro cellular & developmental biology. Animal · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. The many faces of SIRT6 in the retina and retinal pigment epithelium.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xue YangWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jin-Yong ChungWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-8149-584X
Usha RaiWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Noriko EsumiWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA nesumi1@jhmi.edu.ORCID https://orcid.org/0000-0001-7995-4023
University of Maryland, Baltimore · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
Molecular Mechanisms Regulating VMD2 ExpressionR01EY016398 · NEI · JOHNS HOPKINS UNIVERSITY · PI ESUMI, NORIKO · 2006 to 2009
$643k
NEI NIH HHS P30 EY001765NEI NIH HHS R01 EY016398
6 · The paper itself

Abstract

Retinal pigment epithelium (RPE) is essential for the survival of retinal photoreceptors. To study retinal degeneration, sodium iodate (NaIO

Indexed as

Retinal DegenerationSirtuinsAnimalsDNA HelicasesMiceOxidative StressPoly-ADP-Ribose Binding ProteinsRetinal Pigment EpitheliumRNA HelicasesRNA Recognition Motif ProteinsDNA HelicasesPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsSirt6 protein, mouseSirtuins

Identifiers

PMID37185874
PMCPMC10130745
OpenAlexW4366997725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.