Evidence map›Paper›PMID 37185866›Full record

ArticleJournal of medical virology2023

Evaluation of host cellular responses to Epstein-Barr virus (EBV) in adult lung transplant patients with EBV-associated diseases.

Lorenzo Zaffiri, Joshua E Messinger, Erika J Bush, Janet S Staats, Prekshaben Patel, Scott M Palmer, Kent J Weinhold, Laurie D Snyder, Micah A Luftig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lorenzo ZaffiriDivision of Pulmonary and Critical Care, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-8369-4145
Joshua E MessingerDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Erika J BushDivision of Pulmonary and Critical Care, Duke University, Durham, North Carolina, USA.
Janet S StaatsDepartment of Surgery, Duke University, Durham, North Carolina, USA.
Prekshaben PatelDepartment of Surgery, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-6216-1534
Scott M PalmerDivision of Pulmonary and Critical Care, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-1370-3771
Kent J WeinholdDepartment of Surgery, Duke University, Durham, North Carolina, USA.ORCID 0000-0003-4876-6737
Laurie D SnyderDivision of Pulmonary and Critical Care, Duke University, Durham, North Carolina, USA.ORCID 0000-0002-5962-2184
Micah A LuftigDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-2964-1907
Duke University · USCedars-Sinai Medical Center · US

Funding

The Lung Transplant Clinical Trials Network (LT-CTN)U01AI113315 · NIAID · DUKE UNIVERSITY · PI PALMER, SCOTT M · 2014 to 2018
$12.9M
Host pathways regulating Epstein-Barr virus-mediated B cell growth transformationR01CA140337 · NCI · DUKE UNIVERSITY · PI LUFTIG, MICAH ALAN · 2011 to 2025
$5.9M
NCI NIH HHS R01 CA140337NIAID NIH HHS U01 AI113315
6 · The paper itself

Abstract

Epstein-Barr virus (EBV) reactivation is commonly observed in lung transplant recipients (LTRs). However, cellular immune responses to EBV in adult LTRs have not been well described. We aimed to study CD4/CD8 ratio, EBV-specific T cells polyfunctional responses and phenotypic changes in natural killer (NK) cells in adult LTRs presenting with EBV-associated diseases. The CD4/CD8 ratio was significantly decreased in LTRs with EBV DNAemia compared with LTRs without EBV DNAemia and healthy controls (HCs). Stimulation with EBV lytic antigen BZLF1 peptide pools induced significant individual and polyfunctional responses from CD8

Indexed as

Epstein-Barr Virus InfectionsLung TransplantationAdultCD8-Positive T-LymphocytesHerpesvirus 4, HumanHumansInterferon-gammaInterferon-gammaEBVlung transplantNK cellsT cells

Identifiers

PMID37185866
PMCPMC10481801
OpenAlexW4366396601

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.