Evidence map›Paper›PMID 37185549›Full record

ReviewBiosensors2023

Recent Advances in Biomolecular Detection Based on Aptamers and Nanoparticles.

Ruiting Xu, Leixin Ouyang, Heyi Chen, Ge Zhang, Jiang Zhe

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biosensors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruiting XuDepartment of Mechanical Engineering, University of Akron, Akron, OH 44325, USA.
Leixin OuyangDepartment of Mechanical Engineering, University of Akron, Akron, OH 44325, USA.
Heyi ChenDepartment of Mechanical Engineering, University of Akron, Akron, OH 44325, USA.
Ge ZhangDepartment of Biomedical Engineering, University of Akron, Akron, OH 44325, USA.ORCID 0000-0001-8339-1892
Jiang ZheDepartment of Mechanical Engineering, University of Akron, Akron, OH 44325, USA.ORCID 0000-0002-5452-549X

Funding

Molecularly regulated release of angiogenic factors from superporous hydrogelsR01HL122311 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI WANG, YONG · 2015 to 2023
$4.2M
NHLBI NIH HHS R01 HL122311NIH HHS R01HL122311
6 · The paper itself

Abstract

The fast, accurate detection of biomolecules, ranging from nucleic acids and small molecules to proteins and cellular secretions, plays an essential role in various biomedical applications. These include disease diagnostics and prognostics, environmental monitoring, public health, and food safety. Aptamer recognition (DNA or RNA) has gained extensive attention for biomolecular detection due to its high selectivity, affinity, reproducibility, and robustness. Concurrently, biosensing with nanoparticles has been widely used for its high carrier capacity, stability and feasibility of incorporating optical and catalytic activity, and enhanced diffusivity. Biosensors based on aptamers and nanoparticles utilize the combination of their advantages and have become a promising technology for detecting of a wide variety of biomolecules with high sensitivity, reliability, specificity, and detection speed. Via various sensing mechanisms, target biomolecules have been quantified in terms of optical (e.g., colorimetric and fluorometric), magnetic, and electrical signals. In this review, we summarize the recent advances in and compare different aptamer-nanoparticle-based biosensors by nanoparticle types and detection mechanisms. We also share our views on the highlights and challenges of the different nanoparticle-aptamer-based biosensors.

Indexed as

Aptamers, NucleotideBiosensing TechniquesNanoparticlesDNAReproducibility of ResultsAptamers, NucleotideDNAaptameraptasensorcolorimetryelectrochemical sensingfluorometrymagnetic relaxation switchingnanoparticlesresistive pulse sensor

Identifiers

PMID37185549
PMCPMC10136534

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.