Evidence map›Paper›PMID 37185464›Full record

ArticleNature communications2023

Bone marrow endosteal stem cells dictate active osteogenesis and aggressive tumorigenesis.

Yuki Matsushita, Jialin Liu, Angel Ka Yan Chu, Chiaki Tsutsumi-Arai, Mizuki Nagata, Yuki Arai, Wanida Ono, Kouhei Yamamoto, Thomas L Saunders, Joshua D Welch and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Development-based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Article
  7. Stage-resolved geography of mouse skeletal stem cells.Journal of bone and mineral metabolism · 2026
    Review
  8. Skeletal stem cell lineages in osteosarcoma and bone metastasis.Journal of bone and mineral metabolism · 2026
    Review
  9. Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026
    Review
  10. Article
  11. Article
  12. Article
  13. Fibrous-layer resident Angptl7Cell research · 2026
    Article
  14. Review
  15. Review
  16. Early determination of the dorsal-ventral axis in endochondral ossification in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Article
  17. An adipo-osteoprogenitor population in the endosteal niche contributes to bone and fat formation in adult mouse bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Yuki Matsushita *University of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Jialin Liu *Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9984-7695
Angel Ka Yan ChuDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Chiaki Tsutsumi-AraiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Mizuki NagataUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Yuki AraiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Wanida OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Kouhei YamamotoDepartment of Comprehensive Pathology, Tokyo Medical and Dental University, Tokyo, Japan.
Thomas L SaundersTransgenic Animal Model Core, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID 0000-0003-2015-101X
Joshua D WelchDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. welchjd@med.umich.edu.
Noriaki OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA. noriaki.ono@uth.tmc.edu.ORCID 0000-0002-3771-8230
The University of Texas Health Science Center at Houston · USUniversity of Michigan · USNagasaki University · JPThe University of Texas Health Science Center · USTokyo Medical and Dental University · JP

Funding

Quantitative definition of cell identity from single-cell multi-omic, spatial, and perturbation dataR01HG010883 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joshua Welch · 2019 to 2026
$4.4M
Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their nichesR01DE030630 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI, ONO, WANIDA · 2021 to 2025
$2.2M
Dynamics and Regulations of Bone Stem Cells in VivoR01DE026666 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI · 2018 to 2022
$2.1M
Dental Follicle: A Central Regulator of Tooth Root Formation and RegenerationR01DE029181 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, WANIDA · 2021 to 2025
$1.9M
NHGRI NIH HHS R01 HG010883NIDCR NIH HHS R01 DE026666NIDCR NIH HHS R01 DE029181NIDCR NIH HHS R01 DE030630
6 · The paper itself

Abstract

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal compartment, which are important regulators of bone formation. It is well-described that leptin receptor (LepR)

Indexed as

Bone MarrowOsteogenesisAdultAgedBone and BonesBone Marrow CellsCarcinogenesisCell DifferentiationHumansOsteoblastsStem Cells

Identifiers

PMID37185464
PMCPMC10130060
OpenAlexW4366984421

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.