Evidence map›Paper›PMID 37185154›Full record

ArticleJournal of the International Neuropsychological Society : JINS2024

Associations of category fluency clustering performance with

Defne Yucebas, Joshua T Fox-Fuller, Alex Badillo Cabrera, Ana Baena, Celina Pluim McDowell, Paula Aduen, Clara Vila-Castelar, Yamile Bocanegra, Victoria Tirado, Justin S Sanchez and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Defne YucebasDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, 02155, USA.
Joshua T Fox-FullerDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, 02155, USA.
Alex Badillo CabreraDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Ana BaenaGrupo de Neurociencias de Antioquia, University of Antioquia, Medellín, Colombia.
Celina Pluim McDowellDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, 02155, USA.
Paula AduenDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Clara Vila-CastelarDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Yamile BocanegraGrupo de Neurociencias de Antioquia, University of Antioquia, Medellín, Colombia.
Victoria TiradoGrupo de Neurociencias de Antioquia, University of Antioquia, Medellín, Colombia.
Justin S SanchezDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4421-3078
Alice Cronin-GolombDepartment of Psychological and Brain Sciences, Boston University, Boston, MA, 02155, USA.
Francisco LoperaGrupo de Neurociencias de Antioquia, University of Antioquia, Medellín, Colombia.
Yakeel T QuirozDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-9714-8244
Harvard University · USBoston University · USUniversidad de Antioquia · CO

Funding

Relationship between tau pathology and cognitive impairment in autosomal dominant Alzheimer's diseaseR01AG054671 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI QUIROZ, YAKEEL T. · 2017 to 2021
$3.8M
Nerve growth factor (NGF) metabolic dysfunction as a marker of cognitive decline in autosomal dominant Alzheimer's diseaseRF1AG077627 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI AGUILLON, DAVID FERNANDO, CUELLO, A CLAUDIO · 2022 to 2022
$2.0M
Working Memory in Preclinical Alzheimer's Disease: a Neuropsychological and Neuroimaging InvestigationF31AG062158 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI FULLER, JOSHUA THOMAS · 2019 to 2021
$117k
NIA NIH HHS F31 AG062158NIA NIH HHS R01 AG054671NIA NIH HHS RF1 AG077627
6 · The paper itself

Abstract

objectivesAlzheimer's disease (AD) is known to impact semantic access, which is frequently evaluated using the Category Fluency (Animals) test. Recent studies have suggested that in addition to overall category fluency scores (total number of words produced over time), poor clustering could signal AD-related cognitive difficulties. In this study, we examined the association between category fluency clustering performance (i.e., stating words sequentially that are all contained within a subcategory, such as domestic animals) and brain pathology in individuals with autosomal dominant Alzheimer's disease (ADAD).

methodsA total of 29 non-demented carriers of the Presenilin1 E280A ADAD mutation and 32 noncarrier family members completed the category fluency test (Animals) and the Mini-Mental State Examination (MMSE). The participants also underwent positron emission tomography (PET) scans to evaluate

resultsAnimal fluency scores did not differ between carriers and noncarriers. Carriers, however, showed a stronger association between animal fluency clustering and

conclusionThis study indicates that using category fluency clustering, but not total score, is related to AD pathophysiology in the preclinical and early stages of the disease.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAmyloidAmyloid beta-PeptidesBrainHumansPositron-Emission Tomographytau ProteinsAmyloidAmyloid beta-Peptidestau ProteinsAlzheimer-beta proteinAlzheimer’s diseasecognitionneuropsychologypositron-emission tomographytau protein

Identifiers

PMID37185154
PMCPMC10600324
OpenAlexW4367052461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.