Evidence map›Paper›PMID 37184702›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Chemo-Enzymatic Synthesis of Non-ribosomal Macrolactams by a Penicillin-Binding Protein-Type Thioesterase.

Masakazu Kobayashi, Kei Fujita, Kenichi Matsuda, Toshiyuki Wakimoto

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Masakazu Kobayashi *Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Kei Fujita *Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Kenichi MatsudaFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. kematsuda@pharm.hokudai.ac.jp.
Toshiyuki WakimotoFaculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan. wakimoto@pharm.hokudai.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Penicillin-binding protein-type thioesterases (PBP-type TEs) are an emerging family of non-ribosomal peptide cyclases. PBP-type TEs exhibit distinct substrate scopes from the well-exploited ribosomal peptide cyclases and traditional non-ribosomal peptide cyclases. Their unique properties, as well as their stand-alone nature, highlight PBP-type TEs as valuable candidates for development as biocatalysts for peptide macrocyclization. Here in this chapter, we describe the scheme for the chemoenzymatic synthesis of non-ribosomal macrolactam by SurE, a representative member of PBP-type TEs.

Indexed as

HexosyltransferasesPeptidesBacterial ProteinsPenicillin-Binding ProteinsBacterial ProteinsHexosyltransferasesPenicillin-Binding ProteinsPeptidesChemo-enzymatic synthesisCyclic peptidesPenicillin-binding protein-type thioesterasesPeptide cyclase

Identifiers

PMID37184702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.