Evidence map›Paper›PMID 37184598›Full record

ArticleAnnals of intensive care2023

Urinary neutrophil gelatinase-associated lipocalin and plasma IL-6 in discontinuation of continuous venovenous hemodiafiltration for severe acute kidney injury: a multicenter prospective observational study.

Yohei Komaru, Moe Oguchi, Tomohito Sadahiro, Taka-Aki Nakada, Noriyuki Hattori, Takeshi Moriguchi, Junko Goto, Hidetoshi Shiga, Yoshihiko Kikuchi, Shigeo Negi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Yohei KomaruDepartment of Hemodialysis and Apheresis, The University of Tokyo Hospital, Tokyo, Japan.
Moe OguchiDepartment of Emergency and Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
Tomohito SadahiroDepartment of Emergency and Critical Care Medicine, Tokyo Women's Medical University Yachiyo Medical Center, Chiba, Japan.
Taka-Aki NakadaDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Noriyuki HattoriDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Takeshi MoriguchiDepartment of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
Junko GotoDepartment of Emergency and Critical Care Medicine, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan.
Hidetoshi ShigaEmergency and Intensive Care Center, Teikyo University Chiba Medical Center, Chiba, Japan.
Yoshihiko KikuchiEmergency and Intensive Care Center, Teikyo University Chiba Medical Center, Chiba, Japan.
Shigeo NegiDepartment of Nephrology, Wakayama Medical University, Wakayama, Japan.
Takashi ShigematsuDepartment of Nephrology, Wakayama Medical University, Wakayama, Japan.
Naohide KuriyamaDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Tomoyuki NakamuraDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Aichi, Japan.
Kent DoiDepartment of Emergency and Critical Care Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 1138655, Japan. kentdoi@m.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0002-0115-1439
Chiba University · JPFujita Health University · JPTeikyo University Chiba Medical Center · JPTokyo Women's Medical University · JPUniversity of Tokyo Hospital · JPUniversity of Yamanashi · JPWakayama Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with severe acute kidney injury (AKI) who require continuous venovenous hemodiafiltration (CVVHDF) in intensive care unit (ICU) are at high mortality risk. Little is known about clinical biomarkers for risk prediction, optimal initiation, and optimal discontinuation of CVVHDF.

methodsThis prospective observational study was conducted in seven university-affiliated ICUs. For urinary neutrophil gelatinase-associated lipocalin (NGAL) and plasma IL-6 measurements, samples were collected at initiation, 24 h, 48 h after, and CVVHDF discontinuation in adult patients with severe AKI. The outcomes were deaths during CVVHDF and CVVHDF dependence.

resultsA total number of 133 patients were included. Twenty-eight patients died without CVVHDF discontinuation (CVVHDF nonsurvivors). Urinary NGAL and plasma IL-6 at the CVVHDF initiation were significantly higher in CVVHDF nonsurvivors than in survivors. Among 105 CVVHDF survivors, 70 patients were free from renal replacement therapy (RRT) or death in the next 7 days after discontinuation (success group), whereas 35 patients died or needed RRT again (failure group). Urinary NGAL at CVVHDF discontinuation was significantly lower in the success group (93.8 ng/ml vs. 999 ng/ml, p < 0.01), whereas no significant difference was observed in plasma IL-6 between the groups. Temporal elevations of urinary NGAL levels during the first 48 h since CVVHDF initiation were observed in CVVHDF nonsurvivors and those who failed in CVVHDF discontinuation.

conclusionsUrinary NGAL at CVVHDF initiation and discontinuation was associated with mortality and RRT dependence, respectively. The serial changes of urinary NGAL might also help predict the prognosis of patients with AKI on CVVHDF.

Indexed as

Acute kidney injuryContinuous venovenous hemodiafiltrationDiscontinuationInterleukin 6Neutrophil gelatinase-associated lipocalin

Identifiers

PMID37184598
PMCPMC10185728
OpenAlexW4376630716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.