Evidence map›Paper›PMID 37184546›Full record

ArticleBiochemistry2023

Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.

Katarina M Guzman, Dillon P Cogan, Krystal L Brodsky, Alexander M Soohoo, Xiuyuan Li, Natalia Sevillano, Irimpan I Mathews, Khanh P Nguyen, Charles S Craik, Chaitan Khosla

Abstract read
In one paragraph

Article in Biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katarina M GuzmanDepartment of Chemical Engineering, Stanford University, Stanford, California 94305, United States.
Dillon P CoganDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Krystal L BrodskyDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Alexander M SoohooDepartment of Chemical Engineering, Stanford University, Stanford, California 94305, United States.
Xiuyuan LiDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Natalia SevillanoDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.
Irimpan I MathewsStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States.ORCID 0000-0001-6254-3519
Khanh P NguyenDepartment of Chemistry, Stanford University, Stanford, California 94305, United States.
Charles S CraikDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States.ORCID 0000-0001-7704-9185
Chaitan KhoslaDepartment of Chemical Engineering, Stanford University, Stanford, California 94305, United States.ORCID 0000-0001-6529-495X

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Vittorio Sebastiano · 2007 to 2026
$71.4M
X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Renewable antibodies to secreted proteins and single and multi-pass cell surfaceP41CA196276 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WELLS, JAMES A · 2014 to 2018
$5.8M
Mechanisms and Evolution of Assembly-Line Polyketide SynthasesR35GM141799 · NIGMS · STANFORD UNIVERSITY · PI CHAITAN KHOSLA · 2021 to 2026
$2.5M
PILATUS3 X 1M X-ray detectorS10OD021512 · OD · STANFORD UNIVERSITY · PI WEIS, WILLIAM I · 2016 to 2016
$550k
Mechanistic Studies of Polyketide Synthases Enabled by Unnatural Amino Acids and Antibody Fragment Structural ToolsF32GM136039 · NIGMS · STANFORD UNIVERSITY · PI COGAN, DILLON P · 2020 to 2022
$196k
NCI NIH HHS P30 CA124435NCI NIH HHS P41 CA196276NIGMS NIH HHS F32 GM136039NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R35 GM141799NIH HHS S10 OD021512
6 · The paper itself

Abstract

Fragment antigen-binding domains of antibodies (F

Indexed as

ErythromycinPolyketide SynthasesAcyltransferasesAntibodies6-deoxyerythronolide BAcyltransferasesAntibodiesErythromycinPolyketide Synthases

Identifiers

PMID37184546
PMCPMC10274564

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.