Evidence map›Paper›PMID 37184413›Full record

Observational studyEuropean journal of physical and rehabilitation medicine2023

The impact of cognitive function deficits and their recovery on functional outcome in subjects affected by ischemic subacute stroke: results from the Italian multicenter longitudinal study CogniReMo.

Mauro Mancuso, Marco Iosa, Laura Abbruzzese, Alessandro Matano, Michela Coccia, Silvia Baudo, Adonella Benedetti, Carmen Gambarelli, Simona Spaccavento, Giordano Ambiveri and 9 more

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in European journal of physical and rehabilitation medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  10. Treatment with Manganese Porphyrin, MnTnBuOE-2-PyPPharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mauro MancusoUnit of Physical and Rehabilitative Medicine, South-East Tuscany Regional Health Service, Grosseto, Italy.
Marco IosaDepartment of Psychology, Sapienza University, Rome, Italy - marco.iosa@uniroma1.it.
Laura AbbruzzeseTuscany Rehabilitation Clinic, Montevarchi, Arezzo, Italy.
Alessandro MatanoNeuropsychology Center, IRCCS Santa Lucia Foundation, Rome, Italy.
Michela CocciaDepartment of Neurological Sciences, Ospedali Riuniti di Ancona, Ancona, Italy.
Silvia BaudoDivision of Neurology and Neurorehabilitation, IRCCS Istituto Auxologico Italiano, Piancavallo, Verbania, Italy.
Adonella BenedettiUnit of Intensive Neurorehabilitation, Trevi, Perugia, Italy.
Carmen GambarelliDepartment of Physical and Rehabilitative Medicine, University of Modena, Modena, Italy.
Simona SpaccaventoIRCCS Istituti Clinici Scientifici Maugeri SpA SB, Bari, Italy.
Giordano AmbiveriUnit of Neurological Rehabilitation, San Giacomo Hospital, Ponte dell'Olio, Piacenza, Italy.
Marisa MegnaDepartment of Physical and Rehabilitative Medicine, University of Bari, Bari, Italy.
Paola TognettiUnit of Physical and Rehabilitative Medicine, Sestri Levante Hospital, Genoa, Italy.
Alessandra MaiettiUnit of Specialistic Rehabilitation, Poliambulanza Foundation, Brescia, Italy.
Maria L RinaldesiSanto Stefano Rehabilitation Center, Porto Potenza Picena, Macerata, Italy.
Giulia GamberiniDepartment of Rehabilitation, CRRF "Mons. Luigi Novarese", Moncrivello, Vercelli, Italy.
Valentina VaraltaNeuromotor and Cognitive Rehabilitation Research Center, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Giovanni MoroneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Irene CiancarelliDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
CogniReMo Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recovery of independence in activities of daily living is a fundamental goal of rehabilitation programs in subjects affected by subacute stroke. Rehabilitation is focused both on motor and cognitive aspects, and some evidence has reported cognitive deficits as prognostic factors of motor recovery. However, rehabilitation is a dynamic process during which executive functions and motor functions should be improved.

aimThe aim of the study is to evaluate the relationships between impairments in cognitive functions and recovery of functional independence in stroke patients during the subacute phase.

designMulticenter observational study.

settingIntensive rehabilitation units. POPULATION: A sample of 319 stroke patients in subacute phase (70.6±11.6 years, 40.4% females), consecutively admitted from November 2019 to July 2021 at sixteen rehabilitation centers were enrolled in this observational, prospective and multicentric study with longitudinal assessments.

methodsCognitive and functional assessments were performed at hospital admission and discharge, including Oxford Cognitive Screen, modified Barthel Index, Functional Independent Measure, Fugl-Meyer assessment scale and National Institutes of Health Stroke Scale.

resultsA regression analysis identified five predictors (out of about 200 tested variables) of functional recovery related to four aspects assessed at admission: functional status (P<0.001), lower limb functioning (P=0.002), attention (P=0.011), and executive functions (P=0.017). Furthermore, patients who recovered deficits in executive functions had the same recovery of those without deficits, whereas those who maintained deficits had a smaller recovery (P=0.019).

conclusionsThe relationship between cognitive and motor deficits is increasingly highlighted and the recovery of executive functions deficits seems to contribute to motor recovery. CLINICAL REHABILITATION IMPACT: Our results suggest that the recovery of executive functions may promote the recovery of the functional outcome of the patient with subacute stroke. Future treatment protocols may benefit from paying more attention to the recovery of executive functions.

Indexed as

StrokeStroke RehabilitationActivities of Daily LivingCognitionFemaleHumansLongitudinal StudiesMaleProspective StudiesRecovery of FunctionTreatment Outcome

Identifiers

PMID37184413
PMCPMC10266259

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.