Evidence map›Paper›PMID 37184369›Full record

ArticleeLife2023

Nr2f1a maintains atrial

Kendall E Martin, Padmapriyadarshini Ravisankar, Manu Beerens, Calum A MacRae, Joshua S Waxman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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  4. Zebrafish in Cardiovascular Disease Research: from Model to Application.International journal of biological sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kendall E MartinMolecular Genetics, Biochemistry, and Microbiology Graduate Program, University of Cincinnati College of Medicine, Cincinnati, United States.
Padmapriyadarshini RavisankarMolecular Cardiovascular Biology Division and Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.
Manu BeerensDivisions of Cardiovascular Medicine, Genetics and Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Calum A MacRaeDivisions of Cardiovascular Medicine, Genetics and Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Joshua S WaxmanMolecular Cardiovascular Biology Division and Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, United States.ORCID 0000-0002-8132-487X
Cincinnati Children's Hospital Medical Center · USBrigham and Women's Hospital · US

Funding

A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
Molecular Mechanisms of Atrial Development and RegenerationR01HL137766 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Joshua Waxman · 2017 to 2026
$3.9M
Mechanisms governing the differentiation and maintenance of atrial identityR01HL168790 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Joshua Waxman · 2023 to 2026
$2.5M
Mechanisms underlying myxomatous valve diseaseR01HL154522 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WAXMAN, JOSHUA · 2021 to 2024
$2.1M
Retinoic acid-dependent epigenetic and transcriptional mechanisms controlling heart developmentR01HL141186 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI WAXMAN, JOSHUA · 2018 to 2021
$1.6M
Nr2f1a promotes atrial maintenance and ventricular growth in the embryonic zebrafish heartF31HL152600 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MARTIN, KENDALL · 2020 to 2022
$119k
NHLBI NIH HHS F31 HL152600NHLBI NIH HHS R01 HL137766NHLBI NIH HHS R01 HL141186NHLBI NIH HHS R01 HL154522NHLBI NIH HHS R01 HL168790NIH HHS R24 OD017870
6 · The paper itself

Abstract

Maintenance of cardiomyocyte identity is vital for normal heart development and function. However, our understanding of cardiomyocyte plasticity remains incomplete. Here, we show that sustained expression of the zebrafish transcription factor Nr2f1a prevents the progressive acquisition of ventricular cardiomyocyte (VC) and pacemaker cardiomyocyte (PC) identities within distinct regions of the atrium. Transcriptomic analysis of flow-sorted atrial cardiomyocytes (ACs) from

Indexed as

Atrial FibrillationZebrafishAnimalsDNA-Binding ProteinsGene Expression Regulation, DevelopmentalHomeobox Protein Nkx-2.5Homeodomain ProteinsMyocytes, CardiacTranscription FactorsZebrafish ProteinsDNA-Binding ProteinsHomeobox Protein Nkx-2.5Homeodomain Proteinsnr2f1a protein, zebrafishTranscription FactorsZebrafish Proteinsatrial cardiomyocytescell biologycellular plasticitydevelopmental biologyheart developmentNkx2.5 transcription factorNr2f transcription factorpacemaker cardiomyocytezebrafish

Identifiers

PMID37184369
PMCPMC10185342
OpenAlexW4376643063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.