Evidence map›Paper›PMID 37184280›Full record

ArticleActa biochimica et biophysica Sinica2023

Monomethyl fumarate prevents alloimmune rejection in mouse heart transplantation by inducing tolerogenic dendritic cells.

Juntao Chen, Yirui Cao, Ouyang Jia, Xuanchuan Wang, Yongsheng Luo, Yin Celeste Cheuk, Tongyu Zhu, Dong Zhu, Yi Zhang, Jina Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Ginkgolic acid inhibits CD8Journal of pharmaceutical analysis · 2025
    Article
  4. Dendritic cells in liver transplantation immune response.Frontiers in cell and developmental biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Juntao ChenDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yirui CaoDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Ouyang JiaNursing Department of Huashan Hospital Affiliated to Fudan University, Shanghai 200031, China.
Xuanchuan WangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yongsheng LuoDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yin Celeste CheukDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Tongyu ZhuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Dong ZhuDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yi ZhangShanghai Key Laboratory of Organ Transplantation, Shanghai 200032, China.
Jina WangDepartment of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Shanghai Institute of Organic Chemistry · CNSun Yat-sen University · CNZhongshan Hospital · CNFudan University · CNThe First Affiliated Hospital, Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic cells (DCs) are important targets for eliciting allograft rejection after transplantation. Previous studies have demonstrated that metabolic reprogramming of DCs can transform their immune functions and induce their differentiation into tolerogenic DCs. In this study, we aim to investigate the protective effects and mechanisms of monomethyl fumarate (MMF), a bioactive metabolite of fumaric acid esters, in a mouse model of allogeneic heart transplantation. Bone marrow-derived DCs are harvested and treated with MMF to determine the impact of MMF on the phenotype and immunosuppressive function of DCs by flow cytometry and T-cell proliferation assays. RNA sequencing and Seahorse analyses are performed for mature DCs and MMF-treated DCs (MMF-DCs) to investigate the underlying mechanism. Our results show that MMF prolongs the survival time of heart grafts and inhibits the activation of DCs

Indexed as

Heart TransplantationAnimalsDendritic CellsFumaratesGraft RejectionImmune ToleranceMiceMice, Inbred C57BLOrganic ChemicalsT-Lymphocytes, RegulatoryFumaratesmonomethyl fumarateOrganic ChemicalsTolerogendendritic cellheart transplantationimmune tolerancemetabolic reprogrammingmonomethyl fumarateNrf2

Identifiers

PMID37184280
PMCPMC10281873
OpenAlexW4368351824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.