Observational studyAging cell2023
Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.
Observational study in Aging cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Large-scale genome-wide analyses with proteomics integration reveal novel loci and biological insights into frailty.Nature aging · 2025Pooled it
- Combined effect of the triglyceride-glucose index and frailty index on advanced stages among cardiovascular-kidney-metabolic syndrome patients.Journal of cardiothoracic surgery · 2026Article
- The Application of Metabolomics in Frailty: Trends, Challenges, and Future Directions.Metabolites · 2026Review
- The metabolomic signatures mediate associations between physical frailty and metabolic dysfunction-associated steatotic liver disease.Science advances · 2026Article
- The MetaboHealth score is 40% heritable and is influenced by frailty status, BMI, and smoking in Swedish twins.GeroScience · 2026Article
- A blood-based metabolomics study of cardiovascular diseases in Swedish twins reveals apolipoprotein B biology as important for myocardial infarction.GeroScience · 2026Article
- A seven-year longitudinal study of the Alzheimer's disease blood metabolome.medRxiv : the preprint server for health sciences · 2025Article
- Metabolomics-based identification and validation of the creatine precursor guanidinoacetic acid for frailty in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Sex- and system-specific analysis of blood-based biomarkers and frailty in older adults-the Activity and Function of the Elderly study.Age and ageing · 2025Article
- Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty.Aging clinical and experimental research · 2025Article
- Genetic Evidence on the Role of Blood Phytosterols in Frailty: A Mendelian Randomization Study.Food science & nutrition · 2025Article
- Metabolic profiling of frailty, associations with type 2 diabetes and interaction with genetic susceptibility.Cardiovascular diabetology · 2025Article
- U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study.Frontiers in nutrition · 2025Article
- Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study.GeroScience · 2024Article
- Metabolomic and genomic prediction of common diseases in 700,217 participants in three national biobanks.Nature communications · 2024Article
- Temporal Dynamics of Epigenetic Aging and Frailty From Midlife to Old Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The intersection of frailty and metabolism.Cell metabolism · 2024Review
- Metabolic clues to aging: exploring the role of circulating metabolites in frailty, sarcopenia and vascular aging related traits and diseases.Frontiers in genetics · 2024Article
- Association of remnant cholesterol with frailty: findings from observational and Mendelian randomization analyses.Lipids in health and disease · 2023Observational
- Unraveling the metabolic underpinnings of frailty using multicohort observational and Mendelian randomization analyses.Aging cell · 2023Observational
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identifying metabolic biomarkers of frailty, an age-related state of physiological decline, is important for understanding its metabolic underpinnings and developing preventive strategies. Here, we systematically examined 168 nuclear magnetic resonance-based metabolomic biomarkers and 32 clinical biomarkers for their associations with frailty. In up to 90,573 UK Biobank participants, we identified 59 biomarkers robustly and independently associated with the frailty index (FI). Of these, 34 associations were replicated in the Swedish TwinGene study (n = 11,025) and the Finnish Health 2000 Survey (n = 6073). Using two-sample Mendelian randomization, we showed that the genetically predicted level of glycoprotein acetyls, an inflammatory marker, was statistically significantly associated with an increased FI (β per SD increase = 0.37%, 95% confidence interval: 0.12-0.61). Creatinine and several lipoprotein lipids were also associated with increased FI, yet their effects were mostly driven by kidney and cardiometabolic diseases, respectively. Our findings provide new insights into the causal effects of metabolites on frailty and highlight the role of chronic inflammation underlying frailty development.
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