Evidence map›Paper›PMID 37184115›Full record

Trial reportCancer medicine2023

Feasibility of supervised telehealth exercise for patients with advanced melanoma receiving checkpoint inhibitor therapy.

Brendan J Crosby, Robert U Newton, Daniel A Galvão, Dennis R Taaffe, Pedro Lopez, Tarek M Meniawy, Muhammad A Khattak, Wei-Sen Lam, Elin S Gray, Favil Singh

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Using digital technology to support wellbeing and independence among people living with incurable cancers: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Brendan J CrosbyExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Pedro LopezExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.
Tarek M MeniawySchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Muhammad A KhattakSchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Wei-Sen LamDepartment of Medical Oncology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia.
Elin S GraySchool of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
Favil SinghExercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID 0000-0002-4876-2990
Edith Cowan University · AUFiona Stanley Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the feasibility, safety and preliminary efficacy of a telehealth supervised exercise programme in patients with advanced melanoma receiving checkpoint inhibitor therapy.

methodsA 8-week non-randomised feasibility pilot trial utilising a telehealth delivered multimodal exercise programme undertaken thrice weekly with assessments at baseline and post-intervention. The study was considered feasible if there were no severe or life-threatening adverse events as a result of exercise, and three or more of the following criteria were met: the recruitment rate was >50%, completion rate was >80%, median programme attendance was >75%, median exercise compliance >75%, and average tolerance was >70%. Preliminary efficacy was assessed for objective measures of physical function (2-min step test, repeated chair stand test, 30-s push-up test, and a modified static balance test) and quality of life (QoL), fatigue and other patient-reported outcomes were assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30.

resultsEleven patients (32-80 years) were included in the study (6 female, 5 male). The recruitment rate was 48%, completion rate 91%, programme attendance 88%, median exercise compliance 82.1% and 84.9% for resistance and aerobic exercise, respectively, and tolerance 88%, with no severe or life-threatening adverse events as a result of exercise. In terms of preliminary efficacy, physical function significantly improved while QoL was maintained following the intervention.

conclusionAn 8-week telehealth exercise intervention is feasible and safe for patients with advanced melanoma and appears to improve physical function while preserving QoL during checkpoint inhibitor therapy.

Indexed as

MelanomaTelemedicineExerciseExercise TherapyFeasibility StudiesFemaleHumansMaleQuality of Lifeexercisehealth-related outcomesimmunotherapymelanomaquality of lifetelehealth

Identifiers

PMID37184115
PMCPMC10358269
OpenAlexW4376631193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.