Evidence map›Paper›PMID 37184054›Full record

ArticleWomen's health (London, England)

Cancer burden in women with HIV on Medicaid: A nationwide analysis.

Guangjin Zhou, Siran M Koroukian, Suparna M Navale, Nicholas K Schiltz, Uriel Kim, Johnie Rose, Gregory S Cooper, Scott E Moore, Laura J Mintz, Ann K Avery and 2 more

Abstract read
In one paragraph

Article in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guangjin ZhouDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.ORCID 0000-0002-7707-1435
Siran M KoroukianDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Suparna M NavaleCollege of Public Health, Kent State University, Kent, OH, USA.
Nicholas K SchiltzFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Uriel KimDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Johnie RosePopulation Cancer Analytics Shared Resource, Case Comprehensive Cancer Center, Cleveland, OH, USA.
Gregory S CooperDepartment of Internal Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
Scott E MooreFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Laura J MintzSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Ann K AverySchool of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Sudipto MukherjeeSchool of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Sarah C MarktDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Funding

TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3M
Prevention Research Center for Healthy NeighborhoodsU48DP005030 · DP · CASE WESTERN RESERVE UNIVERSITY · PI BORAWSKI, ELAINE A. · 2014 to 2018
$6.8M
Multi-Level Interventions to Reduce Caries Disparities in Primary Care SettingsUH3DE025487 · NIDCR · CASE WESTERN RESERVE UNIVERSITY · PI NELSON, SUCHITRA S. · 2017 to 2021
$5.6M
Health Promotion and Disease Prevention Research CenterU48DP006404 · DP · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WALKER, JEFFERY T · 2018 to 2023
$4.8M
Long-Term Effects of COVID-19 and Health Care Delivery Changes on Populations Living with Multiple Chronic ConditionsR01AG074946 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI COOK, NICOLE JILL, STANGE, KURT C · 2021 to 2025
$2.5M
NCCDPHP CDC HHS U48 DP005030NCCDPHP CDC HHS U48 DP006404NCI NIH HHS P30 CA043703NIA NIH HHS R01 AG074946NIDCR NIH HHS UH3 DE025487
6 · The paper itself

Abstract

backgroundCancer is the leading cause of death in people living with HIV. In the United States, nearly 1 in 4 people living with HIV are women, more than half of whom rely on Medicaid for healthcare coverage.

objectiveThe objective of this study is to evaluate the cancer burden of women living with HIV on Medicaid.

designWe conducted a cross-sectional study of women 18-64 years of age enrolled in Medicaid during 2012, using data from Medicaid Analytic eXtract files.

methodsUsing International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis codes, we identified women living with HIV (n = 72,508) and women without HIV (n = 17,353,963), flagging the presence of 15 types of cancer and differentiating between AIDS-defining cancers and non-AIDS-defining cancers. We obtained adjusted prevalence ratios and 95% confidence intervals for each cancer and for all cancers combined, using multivariable log-binomial models, and additionally stratifying by age and race/ethnicity.

resultsThe highest adjusted prevalence ratios were observed for Kaposi's sarcoma (81.79 (95% confidence interval: 57.11-117.22)) and non-Hodgkin's lymphoma (27.69 (21.67-35.39)). The adjusted prevalence ratios for anal and cervical cancer, both of which were human papillomavirus-associated cancers, were 19.31 (17.33-21.51) and 4.20 (3.90-4.52), respectively. Among women living with HIV, the adjusted prevalence ratio for all cancer types combined was about two-fold higher (1.99 (1.86-2.14)) in women 45-64 years of age than in women 18-44 years of age. For non-AIDS-defining cancers but not for AIDS-defining cancers, the adjusted prevalence ratios were higher in older than in younger women. There was no significant difference in the adjusted prevalence ratios for all cancer types combined in the race/ethnicity-stratified analyses of the women living with HIV cohort. However, in cancer type-specific sub-analyses, differences in adjusted prevalence ratios between Hispanic versus non-Hispanic women were observed. For example, the adjusted prevalence ratio for Hispanic women for non-Hodgkin's lymphoma was 2.00 (1.30-3.07) and 0.73 (0.58-0.92), respectively, for breast cancer.

conclusionCompared to their counterparts without HIV, women living with HIV on Medicaid have excess prevalence of cervical and anal cancers, both of which are human papillomavirus related, as well as Kaposi's sarcoma and lymphoma. Older age is also associated with increased burden of non-AIDS-defining cancers in women living with HIV. Our findings emphasize the need for not only cancer screening among women living with HIV but also for efforts to increase human papillomavirus vaccination among all eligible individuals.

Indexed as

Cost of IllnessHIV InfectionsMedicaidNeoplasmsAdolescentAdultAgedCross-Sectional StudiesFemaleHumansLymphoma, Non-HodgkinPapillomavirus InfectionsPapillomavirus VaccinesSarcoma, KaposiUnited StatesUterine Cervical NeoplasmsPapillomavirus Vaccinesadjusted prevalence ratioAIDS-defining cancerMedicaidnon-AIDS-defining cancerwomen living with HIV infection

Identifiers

PMID37184054
PMCPMC10192809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.