Evidence map›Paper›PMID 37183873›Full record

ArticleJournal of the American Heart Association2023

Progressive Cardiac Metabolic Defects Accompany Diastolic and Severe Systolic Dysfunction in Spontaneously Hypertensive Rat Hearts.

Jie Li, Krzysztof Minczuk, Qiao Huang, Brandon A Kemp, Nancy L Howell, Mahendra D Chordia, R Jack Roy, James T Patrie, Zoraiz Qureshi, Christopher M Kramer and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Jie LiDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.ORCID 0000-0003-1581-4835
Krzysztof MinczukDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.
Qiao HuangDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.ORCID 0000-0002-9044-2464
Brandon A KempDepartment of Medicine, Division of Endocrinology and Metabolism University of Virginia Charlottesville VA.
Nancy L HowellDepartment of Medicine, Division of Endocrinology and Metabolism University of Virginia Charlottesville VA.
Mahendra D ChordiaDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.ORCID 0000-0001-9364-4697
R Jack RoyDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.
James T PatrieDepartment of Public Health Sciences University of Virginia Charlottesville VA.ORCID 0000-0001-7392-830X
Zoraiz QureshiDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.ORCID 0000-0003-3905-5490
Christopher M KramerDepartment of Medicine, Cardiovascular Division University of Virginia Charlottesville VA.ORCID 0000-0003-2057-7731
Frederick H EpsteinDepartment of Biomedical Engineering University of Virginia Charlottesville VA.ORCID 0000-0002-1954-1988
Robert M CareyDepartment of Medicine, Division of Endocrinology and Metabolism University of Virginia Charlottesville VA.ORCID 0000-0001-7238-7396
Bijoy K KunduDepartment of Radiology and Medical Imaging University of Virginia Charlottesville VA.ORCID 0000-0003-2683-9165
Susanna R KellerDepartment of Medicine, Division of Endocrinology and Metabolism University of Virginia Charlottesville VA.ORCID 0000-0002-3089-7766
University of Virginia · USMedical University of Białystok · PL

Funding

Renal AT2 Receptors in HypertensionR01HL128189 · NHLBI · UNIVERSITY OF VIRGINIA · PI KELLER, SUSANNA R · 2016 to 2024
$5.0M
Multiparametric MRI for the investigation of coronary microvascular diseaseR01HL162872 · NHLBI · UNIVERSITY OF VIRGINIA · PI EPSTEIN, FREDERICK H, WOLF, MATTHEW J · 2022 to 2025
$3.0M
Myocardial Metabolic Remodeling in Cardiac HypertrophyR01HL123627 · NHLBI · UNIVERSITY OF VIRGINIA · PI KUNDU, BIJOY K · 2015 to 2018
$1.9M
Trimodal PET/SPECT/CT Preclinical Scanner for Biomedical ResearchS10OD021672 · OD · UNIVERSITY OF VIRGINIA · PI BERR, STUART S. · 2016 to 2016
$1.2M
NHLBI NIH HHS R01 HL123627NHLBI NIH HHS R01 HL128189NHLBI NIH HHS R01 HL162872NIH HHS S10 OD021672
6 · The paper itself

Abstract

Background Cardiac metabolic abnormalities are present in heart failure. Few studies have followed metabolic changes accompanying diastolic and systolic heart failure in the same model. We examined metabolic changes during the development of diastolic and severe systolic dysfunction in spontaneously hypertensive rats (SHR). Methods and Results We serially measured myocardial glucose uptake rates with dynamic 2-[

Indexed as

Heart FailureHypertensionAnimalsBlood PressureDeoxyglucoseGlucoseRatsRats, Inbred SHRRats, Inbred WKYTomography, X-Ray ComputedDeoxyglucoseGlucosecardiac magnetic resonance imagingdiastolic and systolic functiondynamic FDG PETleft ventricular hypertrophymyocardial metabolismspontaneously hypertensive rats

Identifiers

PMID37183873
PMCPMC10227297
OpenAlexW4376641286

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.