Evidence map›Paper›PMID 37183459›Full record

ArticleCurrent medicinal chemistry2024

Emodin Alcohols: Design, Synthesis, Biological Evaluation and Multitargeting Studies with DNA, RNA, and HSA.

Hai-Guang Wang, Hui-Zhen Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Current medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hai-Guang WangSchool of Pharmacy, Linyi University, Linyi 276000, China.
Hui-Zhen ZhangSchool of Pharmacy, Linyi University, Linyi 276000, China.
Linyi University · CN

Funding

COVID-19 Prevention and Control Science and Technology Research Project of Linyi City 2022XGWZ007Doctoral Scientific Research Foundation of Linyi University LYDX2016BS030Key Research and Development Project of Shandong Province 2019GSF108216Shandong Provincial Natural Science Foundation ZR2020QB167
6 · The paper itself

Abstract

objectiveA series of novel emodin alcohols were designed and prepared in an effort to overcome the increasing microorganism resistance.

methodsNovel emodin alcohols were prepared from commercial emodin and different nitrogen-containing heterocycles

resultsEmodin compound 3d containing 2-methyl-5-nitro imidazole ring showed relatively good antimicrobial activity. Notably, it exhibited equivalent activity against

conclusionThis work provides a promising starting point to optimize the structures of emodin derivatives as potent antimicrobial agents.

Indexed as

Drug DesignEmodinMicrobial Sensitivity TestsMolecular Docking SimulationStaphylococcus aureusAlcoholsAnti-Bacterial AgentsDNADNA GyraseHumansMolecular StructureRNASerum Albumin, HumanStructure-Activity RelationshipAlcoholsAnti-Bacterial AgentsDNADNA GyraseEmodinRNASerum Albumin, HumanantibacterialantifungalEmodinhuman serum albumin.Staphylococcus aureus DNAyeast RNA

Identifiers

PMID37183459
OpenAlexW4376569780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.