Evidence map›Paper›PMID 37182843›Full record

ArticleBritish journal of haematology2023

CDK12/13 dual inhibitors are potential therapeutics for acute myeloid leukemia.

Lindsey Savoy, Nicola Long, Hyunjung Lee, Reid Chen, Basil Allen, Hsin-Yun Lin, Cristina Tognon, Sanjay V Malhotra, Jeffrey W Tyner, Haijiao Zhang

Abstract readLetter
In one paragraph

Article in British journal of haematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. CDK12 and CDK13 in oncology: from RNA regulation to therapeutic targeting.Cellular oncology (Dordrecht, Netherlands) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lindsey SavoyDivision of Oncological Sciences, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Nicola LongDivision of Hematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Hyunjung LeeDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Reid ChenDivision of Oncological Sciences, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Basil AllenDivision of Oncological Sciences, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Hsin-Yun LinDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Cristina TognonDivision of Hematology and Medical Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.ORCID 0000-0002-4872-3078
Sanjay V MalhotraCenter for Experimental Therapeutics, Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Jeffrey W TynerDepartment of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.
Haijiao ZhangDivision of Oncological Sciences, Oregon Health & Science University, Knight Cancer Institute, Portland, Oregon, USA.ORCID 0000-0002-0749-9866

Funding

Tumor Intrinsic and Microenvironmental Mechanisms Driving Drug Combination Efficacy and Resistance in AMLU54CA224019 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Anupriya Agarwal · 2017 to 2026
$13.9M
Functional Genomic Discovery of Pathway Targeted and Immune Modulatory Therapeutic Combinations in Hematologic MalignanciesU01CA217862 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DRUKER, BRIAN J, TYNER, JEFFREY WALLACE · 2017 to 2021
$5.3M
Characterization of NUP205 as a haploinsufficient essential gene for the treatment of hematopoietic malignanciesR37CA284012 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Haijiao Zhang · 2024 to 2026
$1.1M
Characterizing the pathogenesis and targeted therapeutics of Wilms' Tumor 1 (WT1) mutations in AMLR00CA237630 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZHANG, HAIJIAO · 2021 to 2023
$747k
Characterizing the pathogenesis and targeted therapeutics of Wilms' Tumor 1 (WT1) mutations in AMLK99CA237630 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZHANG, HAIJIAO · 2019 to 2020
$204k
NCI NIH HHS K99 CA237630NCI NIH HHS R00 CA237630NCI NIH HHS R37 CA284012NCI NIH HHS U01 CA217862NCI NIH HHS U54 CA224019
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Myeloid, AcuteCyclin-Dependent KinasesHumansCDK12 protein, humanCyclin-Dependent Kinases

Identifiers

PMID37182843
PMCPMC10330638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.