ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2024
Neural Circuit Markers of Familial Risk for Depression Among Healthy Youths in the Adolescent Brain Cognitive Development Study.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- The Relationship Between Family History of Depression and Brain Structure and Function: A Systematic Review of Large Cohorts.Biological psychiatry · 2026Pooled it
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Task-state P300 and functional brain network abnormalities in adolescent major depressive disorder: a Stroop paradigm study.Frontiers in psychiatry · 2026Article
- Subcortical resting state functional connectivity as a neural marker of first onset internalizing disorder in high-risk youth.Neuroimage. Reports · 2025Article
- Associations between parental psychopathology and youth functional emotion regulation brain networks.Developmental cognitive neuroscience · 2024Article
- Neural activation and connectivity in offspring of depressed mothers during monetary and social reward tasks.Biological psychology · 2024Article
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14 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFamily history of depression is a robust predictor of early-onset depression, which may confer risk through alterations in neural circuits that have been implicated in reward and emotional processing. These alterations may be evident in youths who are at familial risk for depression but who do not currently have depression. However, the identification of robust and replicable findings has been hindered by few studies and small sample sizes. In the current study, we sought to identify functional connectivity (FC) patterns associated with familial risk for depression.
methodsParticipants included healthy (i.e., no lifetime psychiatric diagnoses) youths at high familial risk for depression (HR) (n = 754; at least one parent with a history of depression) and healthy youths at low familial risk for psychiatric problems (LR) (n = 1745; no parental history of psychopathology) who were 9 to 10 years of age and from the Adolescent Brain Cognitive Development (ABCD) Study sample. We conducted whole-brain seed-to-voxel analyses to examine group differences in resting-state FC with the amygdala, caudate, nucleus accumbens, and putamen. We hypothesized that HR youths would exhibit global amygdala hyperconnectivity and striatal hypoconnectivity patterns primarily driven by maternal risk.
resultsHR youths exhibited weaker caudate-angular gyrus FC than LR youths (α = 0.04, Cohen's d = 0.17). HR youths with a history of maternal depression specifically exhibited weaker caudate-angular gyrus FC (α = 0.03, Cohen's d = 0.19) as well as weaker caudate-dorsolateral prefrontal cortex FC (α = 0.04, Cohen's d = 0.21) than LR youths.
conclusionsWeaker striatal connectivity may be related to heightened familial risk for depression, primarily driven by maternal history. Identifying brain-based markers of depression risk in youths can inform approaches to improving early detection, diagnosis, and treatment.
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