Evidence map›Paper›PMID 37182662›Full record

ArticleThe Journal of pediatrics2023

Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes.

Sarah E Maylott, Elisabeth Conradt, Monica McGrath, Emily A Knapp, Xiuhong Li, Rashelle Musci, Judy Aschner, Lyndsay A Avalos, Lisa A Croen, Sean Deoni and 19 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 19 institutions in 1 country.

Sarah E MaylottDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC; Department of Psychology, University of Utah, Salt Lake City, UT. Electronic address: sarah.maylott@duke.edu.
Elisabeth ConradtDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC; Department of Psychology, University of Utah, Salt Lake City, UT.
Monica McGrathDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Emily A KnappDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Xiuhong LiDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Rashelle MusciDepartment of Mental Health, Johns Hopkins School of Public Health, Baltimore, MD.
Judy AschnerDepartment of Pediatrics, Hackensack Meridian School of Medicine, Nutley, NJ; Albert Einstein College of Medicine, Bronx, NY.
Lyndsay A AvalosDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Lisa A CroenDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Sean DeoniDepartment of Pediatrics and Department of Diagnostic Imaging, Alpert Medical School of Brown University, Providence, RI.
Karen DerefinkoDepartment of Preventive Medicine and Department of Pharmacology, Addiction Science, and Toxicology, The University of Tennessee Health Science Center, Memphis, TN.
Amy ElliottAvera Research Institute and Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, SD.
Julie A HofheimerDepartment of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Leslie D LevePrevention Science Institute, University of Oregon, Eugene, OR.
Juliette C MadanDepartment of Pediatrics, Psychiatry and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH.
Maxwell MansolfDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Liza B MurrisonDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH; Division of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Jenae M NeiderhiserDepartment of Psychology, Penn State University, University Park, PA.
Sally OzonoffDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, CA.
Jonathan PosnerDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC.
Amy SalisburySchool of Nursing, Virginia Commonwealth University, Richmond, VA.
Sheela SathyanarayanaDepartments of Pediatrics, Environmental and Occupational Health Sciences, and Epidemiology, University of Washington, Seattle, WA; Seattle Children's Research Institute, Seattle, WA.
Julie B SchweitzerDepartment of Psychiatry and Behavioral Sciences and the MIND Institute, University of California, Davis, School of Medicine, Sacramento, CA.
Carl SeashoreDepartment of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Meagan E StablerDepartment of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, NH.
Leslie W YoungDepartment of Pediatrics, University of Vermont Medical Center, Burlington, VT.
Steven J OndersmaDivision of Public Health and Department of Obstetrics, Gynecology, & Reproductive Biology, Michigan State University, East Lansing, MI.
Barry LesterCenter for the Study of Children at Risk, Departments of Psychiatry and Pediatrics, Alpert Medical School of Brown University and Women and Infants Hospital, Providence, RI.
program collaborators for Environmental influences on Child Health Outcomes (ECHO)
Michigan State University · USBrown University · USUniversity of North Carolina at Chapel Hill · USDuke University · USJohns Hopkins University · USKaiser Permanente · USUniversity of California, Davis · USCenter for Infectious Disease Research · USDartmouth College · USPennsylvania State University · USUniversity of Oregon · USUniversity of South Dakota · USUniversity of Vermont Medical Center · USAlbert Einstein College of Medicine · USCincinnati Children's Hospital Medical Center · USNorthwestern University · USUniversity of Tennessee Health Science Center · USUniversity of Washington · USVirginia Commonwealth University · US

Funding

Project-005U2COD023375 · OD · DUKE UNIVERSITY · PI JUNFENG ZHANG · 2016 to 2026
$215.9M
ECHODAC (Environmental Influences on Child Health Outcomes Data Analysis Center)U24OD023382 · OD · JOHNS HOPKINS UNIVERSITY · PI Diane J Catellier, LISA P JACOBSON · 2016 to 2026
$148.4M
Wisconsin Infant Study Cohort (WISC) ECHO Pediatric Follow-UpUH3OD023282 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern · 2018 to 2026
$64.8M
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
A prospective study of critical environmental exposures in formative early life that impact lifelong health in rural US children: the New Hampshire Birth Cohort StudyUH3OD023275 · OD · DARTMOUTH COLLEGE · PI MARGARET Rita KARAGAS, Juliette Madan · 2018 to 2026
$44.3M
The ECHO Measurement Core: A Framework and Resource for Assessing Environmental Exposure and Child HealthU24OD023319 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Courtney K Blackwell, RICHARD GERSHON · 2016 to 2026
$43.7M
Prenatal and Early Childhood Pathways To Health:  An Integrated Model of Chemical and Social Exposures, Biological Mechanisms, and Sex-Specific Effects on Neurodevelopment and Respiratory OutcomesUH3OD023271 · OD · UNIVERSITY OF WASHINGTON · PI BUSH, NICOLE RENEE, KARR, CATHERINE J · 2018 to 2022
$37.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Environmental Influences on Childhood Outcomes in the Northern Plains Safe Passage Study CohortsUH3OD023279 · OD · AVERA MCKENNAN · PI Amy J Elliott, Christine W Hockett · 2018 to 2026
$31.7M
Early Life Exposure to Endocrine Disrupting Chemicals and Child Growth, Adiposity, and NeurodevelopmentUH3OD023289 · OD · KAISER FOUNDATION RESEARCH INSTITUTE · PI ASSIAMIRA FERRARA, Monique Marie Hedderson · 2018 to 2026
$25.1M
Understanding Breastfeeding Practices Among ECHO Cohort Participants Before and During/After the COVID-19 PandemicUH3OD023285 · OD · MICHIGAN STATE UNIVERSITY · PI Charles James Barone, MICHAEL R. ELLIOTT · 2018 to 2026
$24.5M
Revisiting ReCHARGE: ECHO Follow up on Middle Childhood and AdolescenceUH3OD023365 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Deborah Hall Bennett, Irva Hertz-Picciotto · 2018 to 2026
$21.9M
NCATS NIH HHS KL2 TR001065NCATS NIH HHS UL1 TR004419NICHD NIH HHS R01 HD034568NICHD NIH HHS UG1 HD087230NIEHS NIH HHS P30 ES010126NIH HHS U24 OD023319NIH HHS U24 OD023382NIH HHS U2C OD023375NIH HHS UG3 OD023244NIH HHS UG3 OD023249NIH HHS UG3 OD023271NIH HHS UG3 OD023282NIH HHS UG3 OD023285NIH HHS UG3 OD023289NIH HHS UG3 OD023320NIH HHS UG3 OD023337NIH HHS UG3 OD023342NIH HHS UG3 OD035513NIH HHS UG3 OD035540NIH HHS UG3 OD035546NIH HHS UH3 OD023244NIH HHS UH3 OD023248NIH HHS UH3 OD023249NIH HHS UH3 OD023268NIH HHS UH3 OD023271NIH HHS UH3 OD023275NIH HHS UH3 OD023279NIH HHS UH3 OD023282NIH HHS UH3 OD023285NIH HHS UH3 OD023286NIH HHS UH3 OD023289NIH HHS UH3 OD023320NIH HHS UH3 OD023328NIH HHS UH3 OD023342NIH HHS UH3 OD023347NIH HHS UH3 OD023348NIH HHS UH3 OD023349NIH HHS UH3 OD023365NIH HHS UH3 OD023389NIH HHS UH3 OD035513NIH HHS UH3 OD035532
6 · The paper itself

Abstract

objectivesTo predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use. STUDY

designAs part of the Environmental influences on Child Health Outcomes Program, we harmonized prenatal substance use data and child behavior outcomes from 2195 women and their 6- to 11-year-old children across 10 cohorts in the US and used latent class-adjusted regression models to predict parent-rated child behavior.

resultsThree latent classes fit the data: low use (90.5%; n = 1986), primarily using no substances; licit use (6.6%; n = 145), mainly using nicotine with a moderate likelihood of using alcohol and marijuana; and illicit use (2.9%; n = 64), predominantly using illicit substances along with a moderate likelihood of using licit substances. Children exposed to primarily licit substances in utero had greater levels of externalizing behavior than children exposed to low or no substances (P = .001, d = .64). Children exposed to illicit substances in utero showed small but significant elevations in internalizing behavior than children exposed to low or no substances (P < .001, d = .16).

conclusionsThe differences in prenatal polysubstance use may increase risk for specific childhood problem behaviors; however, child outcomes appeared comparably adverse for both licit and illicit polysubstance exposure. We highlight the need for similar multicohort, large-scale studies to examine childhood outcomes based on prenatal substance use profiles.

Indexed as

Child Behavior DisordersPrenatal Exposure Delayed EffectsProblem BehaviorSubstance-Related DisordersChildChild BehaviorFemaleHumansLatent Class AnalysisPregnancybehavior problemschild developmentlatent profile analysisopioid useprenatal substance use

Identifiers

PMID37182662
PMCPMC10524438
OpenAlexW4376269507

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.