Evidence map›Paper›PMID 37182660›Full record

ArticleThe Journal of pediatrics2023

Familial Hypercholesterolemia Biomarker Distribution in Dried Blood Spots.

Patrice K Held, Michael Lasarev, Xiao Zhang, Amy E Wiberley-Bradford, Kristin Campbell, Vanessa Horner, Xiangqiang Shao, Megan Benoy, Ann M Dodge, Amy L Peterson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Patrice K HeldDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR; Oregon State Public Health Laboratory, Oregon Health Authority, Hillsboro, OR.
Michael LasarevDepartment of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Xiao ZhangDivision of Pediatric Cardiology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Amy E Wiberley-BradfordWisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Kristin CampbellWisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Vanessa HornerWisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI; Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Xiangqiang ShaoDivision of Pediatric Cardiology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI; Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Megan BenoyPediatric Specialty Clinics, University of Wisconsin Hospital and Clinics, Madison, WI.
Ann M DodgeDivision of Pediatric Cardiology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Amy L PetersonDivision of Pediatric Cardiology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI. Electronic address: apeterson@pediatrics.wisc.edu.
University of Wisconsin–Madison · USOregon Health Authority · USUW Health University Hospital · US

Funding

Biochemical and Molecular Newborn Screening for Familial HypercholesterolemiaR21HD102793 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI PETERSON, AMY LH · 2021 to 2022
$428k
NICHD NIH HHS R21 HD102793
6 · The paper itself

Abstract

objectiveTo evaluate distribution profiles of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (apoB) as candidate markers of familial hypercholesterolemia in newborns, taking into consideration potential confounding factors, such as gestational age, birth weight, sex, and race. STUDY

designTC, LDL-C, and apoB were measured from 10 000 residual deidentified newborn dried blood spot cards. Concentrations for each biomarker were reported as multiples of the median, with emphasis on describing the 99th percentile values based on birth weight, gestational age, sex, and race. Seasonal variation of biomarkers was also explored.

resultsLDL-C and apoB had distribution curves with tails showing extreme elevation, whereas the distribution of TC was less elevated and had the smallest range. Neonates born at early gestational age and low birth weight had significantly greater 99th percentile of multiples of the median values for apoB but not TC or LDL-C. Differences in biomarker concentration based on sex and race were minimal. All biomarkers showed greatest concentrations in the winter as compared with summer months.

conclusionsLDL-C and apoB had distribution curves supporting candidacy for neonatal familial hypercholesterolemia screening. Future studies are needed to correlate newborn screening results with molecular testing to validate these 2 biomarkers, along with measured cholesterol levels later in childhood.

Indexed as

Hyperlipoproteinemia Type IIApolipoproteins BBiomarkersBirth WeightCholesterol, LDLHumansInfant, NewbornApolipoproteins BBiomarkersCholesterol, LDLdried blood spotsnewborn screeningpediatric cholesterol screening

Identifiers

PMID37182660
PMCPMC10524346
OpenAlexW4376269360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.