Evidence map›Paper›PMID 37182518›Full record

ArticleBioorganic & medicinal chemistry2023

Aromatic oligoesters as novel helix mimetic scaffolds.

Muhammed Haque, Theo Flack, Ravi Singh, Archie Wall, Guilherme Vieira de Castro, Lishen Jiang, Andrew J P White, Anna Barnard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Muhammed HaqueDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Theo FlackDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Ravi SinghDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Archie WallDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Guilherme Vieira de CastroDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Lishen JiangDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Andrew J P WhiteDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
Anna BarnardDepartment of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK. Electronic address: a.barnard@imperial.ac.uk.

Funding

Wellcome Trust 105603/Z/14/ZWellcome Trust 213435/Z/18/Z
6 · The paper itself

Abstract

The design, synthesis, and conformational analysis of a novel aromatic oligoester helix mimetic scaffold is reported. A range of amino acid-type side-chain functionality can be readily incorporated into monomer building blocks over three facile synthetic steps. Analysis of representative dimers revealed a stable conformer capable of effective mimicry of a canonical α-helix and the scaffold was found to be surprisingly stable to degradation in aqueous solutions at acidic and neutral pH.

Indexed as

Amino AcidsBiomimeticsProtein Structure, SecondaryAmino AcidsAromatic oligoesterHelix mimeticProtein-protein interactions

Identifiers

PMID37182518
PMCPMC10250785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.