Evidence map›Paper›PMID 37182424›Full record

ArticleJournal of the neurological sciences2023

Elevated brain derived neurotrophic factor in plasma and interleukin-6 levels in cerebrospinal fluid in meningitis compared to cerebral malaria.

Monique F Stins, Agnes Mtaja, Evan Mulendele, Daniel W Mwimbe, Gabriel Pinilla, Mable Mutengo, Carlos A Pardo, James Chipeta

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the neurological sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Monique F StinsJohns Hopkins School of Public Health, Malaria Research Institute, 615N Wolfe Street, SPH E45141, Baltimore, MD 21205, United States of America. Electronic address: mstins@jhmi.edu.
Agnes MtajaUniversity of Zambia School of Medicine, Department of Paediatrics and Child Health, The School of Medicine, University Teaching Hospital Malaria Research Unit (SMUTH-MRU), P.O. Box 50110, Lusaka, Zambia.
Evan MulendeleUniversity of Zambia School of Medicine, Department of Paediatrics and Child Health, The School of Medicine, University Teaching Hospital Malaria Research Unit (SMUTH-MRU), P.O. Box 50110, Lusaka, Zambia.
Daniel W MwimbeUniversity of Zambia School of Medicine, Department of Paediatrics and Child Health, The School of Medicine, University Teaching Hospital Malaria Research Unit (SMUTH-MRU), P.O. Box 50110, Lusaka, Zambia.
Gabriel PinillaJohns Hopkins School of Medicine, Department of Neurology, Division of Neuroimmunology and Neuroinfectious Diseases, 600 N Wolfe Street, Baltimore, MD 21285, United States of America; Icesi University, Department of Clinical Sciences, Calle 18 No. 122-135, Cali 760031, Colombia.
Mable MutengoUniversity of Zambia School of Medicine, Department of Paediatrics and Child Health, The School of Medicine, University Teaching Hospital Malaria Research Unit (SMUTH-MRU), P.O. Box 50110, Lusaka, Zambia.
Carlos A PardoJohns Hopkins School of Medicine, Department of Neurology, Division of Neuroimmunology and Neuroinfectious Diseases, 600 N Wolfe Street, Baltimore, MD 21285, United States of America.
James ChipetaUniversity of Zambia School of Medicine, Department of Paediatrics and Child Health, The School of Medicine, University Teaching Hospital Malaria Research Unit (SMUTH-MRU), P.O. Box 50110, Lusaka, Zambia.
University of Zambia · ZMJohns Hopkins University · USBloomberg (United States) · US

Funding

Chemokines in Zambian children with Cerebral MalariaR21TW009741 · FIC · JOHNS HOPKINS UNIVERSITY · PI STINS, MONIQUE F · 2013 to 2014
$251k
FIC NIH HHS R21 TW009741
6 · The paper itself

Abstract

Neurological infections, such as Cerebral malaria (CM) and meningitis are associated with high mortality and in survivors, particularly young children, persistent neurologic deficits often remain. As brain inflammation plays a role in the development of these neurological sequelae, multiplex assays were used to assess a select set of immune mediators in both plasma and cerebrospinal fluid (CSF) from Zambian children with neurological infections. Both CM and meningitis patients showed high levels of markers for vascular inflammation, such as soluble ICAM-1 and angiopoietins. Although high levels of angiopoietin 1 and angiopoietin 2 were found in the meningitis group, their levels in the CSF were low and did not differ. As expected, there were high levels of cytokines and notably a significantly elevated IL-6 level in the CSF of the meningitis group. Interestingly, although elevated levels BDNF were found, BDNF levels were significantly higher in plasma of the meningitis group but similar in the CSF. The striking differences in plasma BDNF and IL-6 levels in the CSF point to markedly different neuro-pathological processes. Therefore, further investigations in the role of both IL-6 and BDNF in the neurological outcomes are needed.

Indexed as

Malaria, CerebralMeningitisBrain-Derived Neurotrophic FactorChildChild, PreschoolCytokinesHumansInterleukin-6BDNF protein, humanBrain-Derived Neurotrophic FactorCytokinesIL6 protein, humanInterleukin-6Brain-derived-neurotrophic -factorCerebral malariaInflammationInterleukin-6MeningitisPlasmodium

Identifiers

PMID37182424
PMCPMC10330544
OpenAlexW4367672402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.