ArticleChemical science2023
Biomimetic strain-stiffening in fully synthetic dynamic-covalent hydrogel networks.
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Article
- Soft, Reactive, and Alive: A Dynamic Framework for Degradation and Functional Stability of Polymeric Biomaterials.Polymers · 2026Review
- Multiple Dynamic Covalent Bond Crosslinked Ionic Liquids-Based Hydrogel with Stretchable, Rapid Self-Healing and Antibacterial Activity Properties.Gels (Basel, Switzerland) · 2026Article
- Light-assisted 3D bioprinting of tough hydrogels in biomedical applications.Materials today. Bio · 2026Review
- Degradable multi-arm PEG hydrogels with tunable stiffness and diffusivity.Biomaterials science · 2026Article
- Leveraging bond dissociation kinetics to tune shear-thickening behavior in dynamic covalent tetra-PEG hydrogels.Science advances · 2026Article
- Engineering conformational transitions in silk fibroin hydrogels to create advanced dynamic microenvironments for biomedical applications.Regenerative biomaterials · 2026Review
- Granular Hydrogels as Brittle Yield Stress Fluids.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Mechanoresponsive Hydrogels Emerging from Dynamic and Non-Covalent Interactions.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Reciprocity in dynamics of supramolecular biosystems for the clustering of ligands and receptors.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Tension-induced directional migration of hepatic stellate cells potentially coordinates liver fibrosis progression.Nature biomedical engineering · 2025Article
- Designing Dynamic Hydrogels: The Interplay of Cross-Linker Length, Valency, and Reaction Kinetics in Hydrazone-Based Networks.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Cross-Linker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels.Advanced healthcare materials · 2024Article
- Composite Hydrogels with Rapid Self-Healing, Stretchable, Moldable and Antibacterial Properties Based on PVA/ε-Poly-l-lysine/Hyaluronic Acid.Molecules (Basel, Switzerland) · 2024Article
- Nature's Load-Bearing Design Principles and Their Application in Engineering: A Review.Biomimetics (Basel, Switzerland) · 2024Review
- Well-Defined Synthetic Copolymers with Pendant Aldehydes Form Biocompatible Strain-Stiffening Hydrogels and Enable Competitive Ligand Displacement.Journal of the American Chemical Society · 2024Article
- Boronate Ester Hydrogels for Biomedical Applications: Challenges and Opportunities.Chemistry of materials : a publication of the American Chemical Society · 2024Review
- Using Chemistry To Recreate the Complexity of the Extracellular Matrix: Guidelines for Supramolecular Hydrogel-Cell Interactions.Journal of the American Chemical Society · 2024Review
- Nonlinear Elastic Bottlebrush Polymer Hydrogels Modulate Actomyosin Mediated Protrusion Formation in Mesenchymal Stromal Cells.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Crosslinker Architectures Impact Viscoelasticity in Dynamic Covalent Hydrogels.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanoresponsiveness is a ubiquitous feature of soft materials in nature; biological tissues exhibit both strain-stiffening and self-healing in order to prevent and repair deformation-induced damage. These features remain challenging to replicate in synthetic and flexible polymeric materials. In recreating both the mechanical and structural features of soft biological tissues, hydrogels have been often explored for a number of biological and biomedical applications. However, synthetic polymeric hydrogels rarely replicate the mechanoresponsive character of natural biological materials, failing to match both strain-stiffening and self-healing functionality. Here, strain-stiffening behavior is realized in fully synthetic ideal network hydrogels prepared from flexible 4-arm polyethylene glycol macromers
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.