ArticleChemical science2023
Monitoring amyloid aggregation
Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Minimum effort, maximum effect: modulating twisted intramolecular charge transfer for ultralong room temperature phosphorescence.Chemical science · 2026Article
- Cyclization Matters: Structure-Property Relationship in π-Conjugated Donor-Acceptor Macrocycle Versus Its Linear Analogue.Chemistry, an Asian journal · 2026Article
- Molecular rotor-based probes for protein monitoring in biomedical research.Nature reviews. Chemistry · 2026Review
- Deprotonation- and TICT-triggered ultra-large Stokes shift of aqueous NIR-emissive hydroxylstryryl-pyridinium derivatives.RSC advances · 2026Article
- Phenothiazine-Based Fluorescence-Quenched Photoacoustic Contrast Agents for Molecular Imaging.Chemical & biomedical imaging · 2025Article
- Imaging lipid deposition induced by local hypoxia in degenerative aortic valve disease using a twisted intramolecular charge transfer (TICT)-based lipid droplet-targeting probe.Mikrochimica acta · 2025Article
- Spectral Heterogeneity of Thioflavin T Binding to Aβ42:Aβ40 Mixed Fibrils: Implications for Alzheimer's Disease Screening.ACS omega · 2025Article
- Harnessing Cyanine-like Properties to Develop Bright Fluorogenic Probes Based on Viscosity-Sensitive Molecular Rotors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Exploring the interplay between zinc-induced protein dyshomeostasis and mitochondrial dysfunction using viscosity-sensitive sensor.Smart molecules : open access · 2024Article
- A firm-push-to-open and light-push-to-lock strategy for a general chemical platform to develop activatable dual-modality NIR-II probes.Science advances · 2024Article
- Aryl-Modified Pentamethyl Cyanine Dyes at the C2' Position: A Tunable Platform for Activatable Photosensitizers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Chemical Regulation of Fluorescence Lifetime.Chemical & biomedical imaging · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Imaging amyloid-beta (Aβ) aggregation is critical for understanding the pathology and aiding the pre-symptomatic intervention of Alzheimer's disease (AD). Amyloid aggregation consists of multiple phases with increasing viscosities and demands probes with broad dynamic ranges and gradient sensitivities for continuous monitoring. Yet, existing probes designed based on the twisted intramolecular charge transfer (TICT) mechanism mainly focused on donor engineering, limiting the sensitivities and/or dynamic ranges of these fluorophores to a narrow window. Herein, using quantum chemical calculations, we investigated multiple factors affecting the TICT process of fluorophores. It includes the conjugation length, the net charge of the fluorophore scaffold, the donor strength, and the geometric pre-twisting. We have established an integrative framework for tuning TICT tendencies. Based on this framework, a platter of hemicyanines with varied sensitivities and dynamic ranges is synthesized, forming a sensor array and enabling the observation of various stages of Aβ aggregations. This approach will significantly facilitate the development of TICT-based fluorescent probes with tailored environmental sensitivities for numerous applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.