Evidence map›Paper›PMID 37181541›Full record

ArticleCritical care explorations2023

Therapeutic Effect of Argatroban During Cardiopulmonary Resuscitation and Streptokinase During Extracorporeal Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest.

Jensyn J VanZalen, Stephen Harvey, Pavel Hála, Annie Phillips, Takahiro Nakashima, Emre Gok, Mohamad Hakam Tiba, Brendan M McCracken, Joseph E Hill, Jinhui Liao and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Jensyn J VanZalenDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Stephen HarveyDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Pavel HálaDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Annie PhillipsDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Takahiro NakashimaDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Emre GokDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Mohamad Hakam TibaDepartment of Emergency Medicine and The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan Medical School, Ann Arbor, MI.
Brendan M McCrackenDepartment of Emergency Medicine and The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan Medical School, Ann Arbor, MI.
Joseph E HillDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Jinhui LiaoDepartment of Emergency Medicine and The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan Medical School, Ann Arbor, MI.
Joshua JungDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Joshua MergosMovement Science, University of Michigan School of Kinesiology, Ann Arbor, MI.
William C StaceyDepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI.
Robert H BartlettDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Cindy H HsuDepartment of Emergency Medicine and The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan Medical School, Ann Arbor, MI.
Alvaro Rojas-PeñaDepartment of Surgery and Extracorporeal Life Support Laboratory, University of Michigan Medical School, Ann Arbor, MI.
Robert W NeumarDepartment of Emergency Medicine and The Max Harry Weil Institute for Critical Care Research and Innovation, University of Michigan Medical School, Ann Arbor, MI.
University of Michigan–Ann Arbor · US

Funding

ECPR After Prolonged Cardiac Arrest: Targeting Mechanisms of the No-ReflowR01HL133129 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARTLETT, ROBERT H., NEUMAR, ROBERT W. · 2017 to 2020
$3.1M
NHLBI NIH HHS R01 HL133129
6 · The paper itself

Abstract

Prolonged cardiac arrest (CA) causes microvascular thrombosis which is a potential barrier to organ reperfusion during extracorporeal cardiopulmonary resuscitation (ECPR). The aim of this study was to test the hypothesis that early intra-arrest anticoagulation during cardiopulmonary resuscitation (CPR) and thrombolytic therapy during ECPR improve recovery of brain and heart function in a porcine model of prolonged out-of-hospital CA.

designRandomized interventional trial.

settingUniversity laboratory. SUBJECTS: Swine.

interventionsIn a blinded study, 48 swine were subjected to 8 minutes of ventricular fibrillation CA followed by 30 minutes of goal-directed CPR and 8 hours of ECPR. Animals were randomized into four groups ( MEASUREMENTS AND MAIN

resultsPrimary outcomes included recovery of cardiac function measured by cardiac resuscitability score (CRS: range 0-6) and recovery of brain function measured by the recovery of somatosensory-evoked potential (SSEP) cortical response amplitude. There were no significant differences in recovery of cardiac function as measured by CRS between groups (

conclusionsIn this swine model of prolonged CA treated with ECPR, early intra-arrest anticoagulation during goal-directed CPR and thrombolytic therapy during ECPR did not improve initial recovery of heart and brain function but did reduce histologic evidence of ischemic injury. The impact of this therapeutic strategy on the long-term recovery of cardiovascular and neurological function requires further investigation.

Indexed as

animal modelsanticoagulantscardiopulmonary resuscitationextracorporeal supportthrombolytics

Identifiers

PMID37181541
PMCPMC10174369
OpenAlexW4376138337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.