Evidence map›Paper›PMID 37181427›Full record

ArticleFrontiers in pediatrics2023

Physician-defined severe toxicities occurring during and after cancer treatment: Modified consensus definitions and clinical applicability in the evaluation of cancer treatment.

Camilla Grud Nielsen, Birthe Lykke Thomsen, Bodil Als-Nielsen, Rachel Conyers, Sima Jeha, Marion K Mateos, Wojciech Mlynarski, Rob Pieters, Mathias Rathe, Kjeld Schmiegelow and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05639673 (Severe Toxicity Free Survival Following Childhood Acute Lymphoblastic Leukemia), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05639673 unknown statusnot on this map

Severe Toxicity Free Survival Following Childhood Acute Lymphoblastic Leukemia

TypeobservationalSponsorRigshospitalet, DenmarkRan2023 to 2025Enrolled5,000ConditionsAcute Lymphoblastic Leukemia
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Camilla Grud NielsenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Birthe Lykke ThomsenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Bodil Als-NielsenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Rachel ConyersDepartment of Paediatrics, University of Melbourne, Melbourne, VIC, Australia.
Sima JehaDepartment of Oncology, St Jude Children's Research Hospital, Memphis, TN, United States.
Marion K MateosKids Cancer Centre, Sydney Children's Hospital Randwick, Sydney, NSW, Australia.
Wojciech MlynarskiDepartment of Pediatrics, Oncology & Hematology, Medical University of Lodz, Lodz, Poland.
Rob PietersPrincess Maxima Center for Pediatric Oncology, Utrecht, Netherlands.
Mathias RatheDepartment of Pediatric Hematology and Oncology, Hans Christian Andersen's Children's Hospital, Odense University Hospital, Odense, Denmark.
Kjeld SchmiegelowDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Liv Andrés-JensenDepartment of Pediatrics and Adolescent Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Copenhagen University Hospital · DKCancer Institute of New South Wales · AUMedical University of Lodz · PLPrincess Máxima Center · NLRoyal Children's Hospital · AUSt. Jude Children's Research Hospital · USUniversity of Copenhagen · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overall survival after cancer is increasing for the majority of cancer types, but survivors can be burdened lifelong by treatment-related severe toxicities. Integration of long-term toxicities in treatment evaluation is not least important for children and young adults with cancers with high survival probability. We present modified consensus definitions of 21 previously published physician-defined Severe Toxicities (STs), each reflecting the most serious long-term treatment-related toxicities and representing an unacceptable price for cure. Applying the Severe Toxicity (ST) concept to real-world data required careful adjustments of the original consensus definitions, translating them into standardized endpoints for evaluating treatment-related outcomes to ensure that (1) the STs can be classified uniformly and prospectively across different cohorts, and (2) the ST definitions allow for valid statistical analyses. The current paper presents the resulting modified consensus definitions of the 21 STs proposed to be included in outcome reporting of cancer treatment.

Indexed as

cancer treatmentchildhood cancerlong-termsevere-toxicity-free-survivaltoxicities

Identifiers

PMID37181427
PMCPMC10171426
OpenAlexW4367053496

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.