Evidence map›Paper›PMID 37181331›Full record

ArticleHGG advances2023

Elizabeth A Werren, Alba Guxholli, Natasha Jones, Matias Wagner, Iris Hannibal, Jorge L Granadillo, Amanda V Tyndall, Amanda Moccia, Ryan Kuehl, Kristin M Levandoski and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 8 institutions in 4 countries.

Elizabeth A WerrenDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Alba GuxholliDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Natasha JonesSchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Matias WagnerInstitute of Human Genetics, Technical University of Munich, 80333 Munich, Germany.
Iris HannibalInstitute of Human Genetics, Technical University of Munich, 80333 Munich, Germany.
Jorge L GranadilloDivision of Genetics and Genomic Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Amanda V TyndallDepartment of Medical Genetics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Amanda MocciaDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ryan KuehlSaint Peter's University Hospital, New Brunswick, NJ 08901, USA.
Kristin M LevandoskiSaint Peter's University Hospital, New Brunswick, NJ 08901, USA.
Debra L Day-SalvatoreSaint Peter's University Hospital, New Brunswick, NJ 08901, USA.
Marsha WheelerDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
University of Washington Center for Mendelian Genomics
Jessica X ChongDepartment of Pediatrics, University of Washington, Seattle, WA 98195, USA.
Michael J BamshadDepartment of Pediatrics, University of Washington, Seattle, WA 98195, USA.
A Micheil InnesDepartment of Medical Genetics, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Tyler Mark PiersonDivision of Pediatric Neurology, Department of Pediatrics, Guerin Children's, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Joel P MackaySchool of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia.
Stephanie L BielasDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Donna M MartinDepartment of Human Genetics, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
University of Michigan · USSaint Peter's University Hospital · USUniversity of Washington · USTechnical University of Munich · DEThe University of Sydney · AUUniversity of Calgary · CACedars-Sinai Medical Center · USWashington University in St. Louis · US

Funding

UW Center for Mendelian GenomicsUM1HG006493 · NHGRI · UNIVERSITY OF WASHINGTON · PI BAMSHAD, MICHAEL JOSEPH, LEAL, SUZANNE M · 2016 to 2020
$15.3M
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
NHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9M
Epigenetics of Inner ear neurosensory cell developmentR01DC018404 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KWAN, KELVIN Y., MARTIN, DONNA M. · 2020 to 2024
$2.7M
Role of histone ubiquitination in neurodevelopment and diseaseR01NS101597 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BIELAS, STEPHANIE LEE · 2018 to 2022
$2.0M
NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006493NIDCD NIH HHS R01 DC018404NIGMS NIH HHS T32 GM007544NINDS NIH HHS R01 NS101597
6 · The paper itself

Abstract

GATA zinc finger domain containing 2A (GATAD2A) is a subunit of the nucleosome remodeling and deacetylase (NuRD) complex. NuRD is known to regulate gene expression during neural development and other processes. The NuRD complex modulates chromatin status through histone deacetylation and ATP-dependent chromatin remodeling activities. Several neurodevelopmental disorders (NDDs) have been previously linked to variants in other components of NuRD's chromatin remodeling subcomplex (NuRDopathies). We identified five individuals with features of an NDD that possessed

Indexed as

Mi-2 Nucleosome Remodeling and Deacetylase ComplexNeurodevelopmental DisordersRepressor ProteinsDNA HelicasesHumansNerve Tissue ProteinsNucleosomesCHD5 protein, humanDNA HelicasesGATAD2A protein, humanMi-2 Nucleosome Remodeling and Deacetylase ComplexNerve Tissue ProteinsNucleosomesRepressor ProteinsGATAD2Aneurodevelopmental disorderNuRD complexNuRDopathies

Identifiers

PMID37181331
PMCPMC10172836
OpenAlexW4366525930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.