Evidence map›Paper›PMID 37181039›Full record

ArticleFrontiers in endocrinology2023

Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis.

Li Bao, Yu-Tong Wang, Min-Qiu Lu, Bin Chu, Lei Shi, Shan Gao, Li-Juan Fang, Qiu-Qing Xiang, Yue-Hua Ding, Xi Liu and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Lipid metabolic vulnerabilities of multiple myeloma.Clinical and experimental medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Li BaoDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Yu-Tong WangDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Min-Qiu LuDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Bin ChuDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Lei ShiDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Shan GaoDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Li-Juan FangDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Qiu-Qing XiangDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Yue-Hua DingDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Xi LiuDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Xin ZhaoDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Meng-Zhen WangDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Yuan ChenDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Wei-Kai HuDepartment of Hematology, Beijing JiShuiTan Hospital, The Fourth Clinical Medical College of Peking University, Beijing, China.
Beijing Jishuitan Hospital · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Vitamin D deficiency is frequent in patients with multiple myeloma (MM), however, its prognostic relevance in MM was rather inconclusive. We first investigated the association of vitamin D deficiency with abnormal bone and lipid metabolism in newly diagnosed multiple myeloma (NDMM), and next assessed the impact of serum ratio of vitamin D to carboxy-terminal telopeptide of type I collagen (β-CTX) on progression-free survival (PFS) and overall free survival (OS) in patients with NDMM. Methods: The data of 431 consecutive patients with NDMM at Beijing Jishuitan Hospital from September 2013 to December 2022 were collected and retrospectively reviewed through our electronic medical record system. The measurement of 25-hydroxyvitamin D in the blood is an indicator of an individual's overall vitamin D status. Results: The serum levels of vitamin D were negatively correlated with β-CTX in NDMM patients. Of note, positive correlation between vitamin D and cholesterol levels in the serum was found in this study. The cohort (n = 431) was divided into two groups based on the serum ratio of vitamin D to β-CTX. Compared to the group with a higher vitamin D to β-CTX ratio, the group with a lower vitamin D to β-CTX ratio (n = 257, 60%) exhibited hypocholesterolemia, inferior PFS and OS, along with increased cases of ISS stage-III and R-ISS stage-III, a higher number of plasma cells in the bone marrow, and elevated serum calcium levels. Consistent with this, multivariate analysis confirmed that the vitamin D to β-CTX ratio was an independent unfavorable indicator for survival in NDMM patients. Conclusion: Our data demonstrated the ratio of vitamin D to β-CTX in the serum is a unique biomarker for NDMM patients to identify the high-risk cases with poor prognosis, which is superior to vitamin D itself for predicting PFS and OS in NDMM. Also, it is worth mentioning that our data on the connection between vitamin D deficiency and hypocholesterolemia might help clarify novel mechanistic aspects of myeloma development.

Indexed as

Multiple MyelomaVitamin D DeficiencyCollagenHumansLipid MetabolismPrognosisRetrospective StudiesVitamin DCollagenVitamin Dcholesterolnewly diagnosed multiple myelomapoor survivalratio of vitamin D to β-CTXvitamin D

Identifiers

PMID37181039
PMCPMC10173308
OpenAlexW4367181183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.