ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Feasibility and acceptability of remote smartphone cognitive testing in frontotemporal dementia research.
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Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
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22 citing papers in PubMed, 16 citations in OpenAlex.
- Longitudinal Cognitive Function in Progressive Supranuclear Palsy-A Review of the Evidence for Progression.Movement disorders clinical practice · 2026Review
- In-clinic validation of a smartphone-based finger tapping test for use in neurodegenerative and neurological populations.medRxiv : the preprint server for health sciences · 2026Article
- Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Implementing Technology in Neuropsychological Assessments: A Scoping Review.Journal of medical systems · 2026Article
- Review of Artificial Intelligence for Clinical Use in Alzheimer's Disease and Related Dementias.Seminars in neurology · 2026Review
- Executive functions in adults: scoping review of computerized neuropsychological batteries.Dementia & neuropsychologia · 2026Review
- From clinical phenotypes to molecular precision: multimodal biomarkers for progressive supranuclear palsy.Frontiers in neuroscience · 2026Review
- A Pocket Laboratory for Functional Neuroimaging Research Using Mobile Visual Oddball, Multimodal Electroencephalography, and Functional Near-Infrared Spectroscopy Imaging: Instrument Validation Study.JMIR neurotechnology · 2026Article
- Design considerations for C9orf72 disease prevention trials.Brain : a journal of neurology · 2025Review
- Remote, self-administered, smartphone cognitive testing in a registry-based cohort: Feasibility, reliability, and validity findings.medRxiv : the preprint server for health sciences · 2025Article
- Digital Health in Parkinson's Disease and Atypical Parkinsonism-New Frontiers in Motor Function and Physical Activity Assessment: Review.Journal of clinical medicine · 2025Review
- Developing digital health technologies for frontotemporal degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- 2024 VCP International Conference: Exploring multi-disciplinary approaches from basic science of valosin containing protein, an AAA+ ATPase protein, to the therapeutic advancement for VCP-associated multisystem proteinopathy.Neurobiology of disease · 2025Review
- Detecting early cognitive deficits in preclinical Alzheimer's disease using a remote digital multi-day learning paradigm.NPJ digital medicine · 2025Article
- Unlocking Cognitive Analysis Potential in Alzheimer's Disease Clinical Trials: Investigating Hierarchical Linear Models for Analyzing Novel Measurement Burst Design Data.Statistics in medicine · 2024Article
- A framework for translating tauopathy therapeutics: Drug discovery to clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.JMIR aging · 2024Article
- Reliability and Validity of Smartphone Cognitive Testing for Frontotemporal Lobar Degeneration.JAMA network open · 2024Article
- Executive Summary of 2023 International Conference of the Korean Dementia Association (IC-KDA 2023): A Report From the Academic Committee of the Korean Dementia Association.Dementia and neurocognitive disorders · 2024Review
- Remote data collection speech analysis in people at risk for Alzheimer's disease dementia: usability and acceptability results.Frontiers in dementia · 2023Article
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Authors and funding
42 authors at 17 institutions in 2 countries.
Jack Carson TaylorDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.ORCID https://orcid.org/0000-0002-6431-9956
Hilary W HeuerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Annie L ClarkDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Amy B WiseDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Masood ManoochehriDepartment of Neurology Columbia University New York New York USA.
Leah ForsbergDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Carly MesterDepartment of Quantitative Health Sciences Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA.
Meghana RaoDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Daniell BrushaberDepartment of Quantitative Health Sciences Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA.
Joel KramerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Ariane E WelchDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
John KornakDepartment of Epidemiology and Biostatistics University of California San Francisco California USA.
Walter KremersDepartment of Quantitative Health Sciences Division of Biomedical Statistics and Informatics Mayo Clinic Rochester Minnesota USA.
Brian ApplebyDepartment of Neurology Case Western Reserve University Cleveland Ohio USA.
Bradford C DickersonDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Kimiko Domoto-ReillyDepartment of Neurology University of Washington Seattle Washington USA.
Julie A FieldsDepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA.
Nupur GhoshalCenter for Advanced Medicine Memory Diagnostic Center Washington University Saint Louis Missouri USA.
Neill Graff-RadfordDepartment of Neuroscience Mayo Clinic Jacksonville Florida USA.
Murray GrossmanDepartment of Neurology University of Pennsylvania Philadelphia Pennsylvania USA.
Matthew Gh HallDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Edward D HueyDepartment of Neurology Columbia University New York New York USA.
David IrwinDepartment of Neurology University of Pennsylvania Philadelphia Pennsylvania USA.
Maria I LapidDepartment of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA.
Irene LitvanDepartment of Neurosciences University of California San Diego California USA.
Ian R MackenzieDepartment of Pathology University of British Columbia Vancouver British Columbia Canada.
Joseph C MasdeuDepartment of Neurology Houston Methodist Houston Texas USA.
Mario F MendezDepartment of Neurology University of California Los Angeles California USA.
Naomi NevlerDepartment of Neurology University of Pennsylvania Philadelphia Pennsylvania USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences Johns Hopkins University Baltimore Maryland USA.
Belen PascualDepartment of Neurology Houston Methodist Houston Texas USA.
Peter PressmanDepartment of Neurology University of Colorado Aurora Colorado USA.
Katherine P RankinDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Buddhika RatnasiriDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Julio C RojasDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Maria Carmela TartagliaTanz Centre for Research in Neurodegenerative Diseases, Division of Neurology University of Toronto Toronto Ontario Canada.
Bonnie WongDepartment of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Bradley F BoeveDepartment of Neurology Mayo Clinic Rochester Minnesota USA.
Howard J RosenDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Adam L BoxerDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.
Adam M StaffaroniDepartment of Neurology, Memory and Aging Center, University of California, San Francisco Weill Institute for Neurosciences San Francisco California USA.ORCID https://orcid.org/0000-0002-3903-9805
University of California, San Francisco · USMayo Clinic · USMayo Clinic in Florida · USUniversity of Pennsylvania · USColumbia University · USHarvard University · USHouston Methodist · USCase Western Reserve University · USJacksonville College · USJohns Hopkins University · USUniversity of British Columbia · CAUniversity of California, Los Angeles · USUniversity of California San Diego · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Toronto · CAUniversity of Washington · USWashington University in St. Louis · US
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MNational Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MPrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1MThe Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MNIA NIH HHS K23 AG059888NIA NIH HHS K23 AG061253NIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066509NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG032306NIA NIH HHS R01 AG038791NIA NIH HHS R01 AG062268NIA NIH HHS R01 AG077557NIA NIH HHS RF1 AG032289NIA NIH HHS RF1 AG077557NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG045390NIA NIH HHS U01 AG079850NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG072122NIDCD NIH HHS K24 DC015544NIMH NIH HHS R01 MH120794NINDS NIH HHS R01 NS050915NINDS NIH HHS R56 NS050915NINDS NIH HHS RF1 NS050915NINDS NIH HHS U54 NS092089
Abstract
Introduction: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp). Methods: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD = 0 [ Results: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity was associated with poorer performance across several tests. Discussion: These findings suggest that the ALLFTD-mApp study protocol is feasible and acceptable for remote FTD research. HIGHLIGHTS: The ALLFTD Mobile App is a smartphone-based platform for remote, self-administered data collection.The ALLFTD Mobile App consists of a comprehensive battery of surveys and tests of executive functioning, memory, speech and language, and motor abilities.Remote digital data collection using the ALLFTD Mobile App was feasible in a multicenter research consortium that studies FTD. Data was collected in healthy controls and participants with a range of diagnoses, particularly FTD spectrum disorders.Remote digital data collection was well accepted by participants with a variety of diagnoses.
Indexed as
adherencecognitiondigital technologyfrontotemporal lobar degeneration (ftld)neuropsychologyprimary progressive aphasia (ppa)smartphone
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