ReviewAging brain2023
Longitudinal association between ß-amyloid accumulation and cognitive decline in cognitively healthy older adults: A systematic review.
Review in Aging brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association between amyloid-β deposition and cognitive function in cognitively normal adults: a multilevel meta-analysis.Alzheimer's research & therapy · 2026Pooled it
- Evaluating the 8-Year Association Between Cognition and Beta Amyloid in the Dallas Lifespan Brain Study Cohort.Brain and behavior · 2026Article
- Divergent patterns of cognitive decline in preclinical Alzheimer's disease: Implications for secondary prevention trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Divergent patterns of cognitive decline in preclinical Alzheimer's disease: implications for secondary prevention trials.medRxiv : the preprint server for health sciences · 2026Article
- Longitudinal Associations of Multimodal Core 1 Alzheimer Disease Biomarkers With Cognition in Aging and Preclinical Alzheimer Disease.Neurology · 2025Observational
- Predicting future cognitive impairment in preclinical Alzheimer's disease using multimodal imaging: a multisite machine learning study.medRxiv : the preprint server for health sciences · 2025Article
- Ensemble survival analysis for preclinical cognitive decline prediction in Alzheimer's disease using longitudinal biomarkers.Journal of Alzheimer's disease : JAD · 2025Article
- Educational attainment, electroencephalographic rhythms, cortical structure, and cognitive performance over 2 years in older adults with subjective memory complaints and brain amyloidosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease.Aging and disease · 2025Article
- Changes in dementia risk along with onset age of depression: a longitudinal cohort study of elderly depressed patients.BMC psychiatry · 2025Article
- Oxidative Stress and Risk of Dementia in Older Patients with Depression: A Longitudinal Cohort Study Using Plasma Biomarkers.Medicina (Kaunas, Lithuania) · 2025Article
- Microvascular dysfunction in a murine model of Alzheimer's disease using intravital microscopy.Frontiers in aging neuroscience · 2025Article
- Brain amyloid load, subjective memory complaints, and cognitive trajectories in older individuals at risk for dementia.European journal of neurology · 2024Article
- A Scoping Review of Alzheimers Disease Hypotheses: An Array of Uni- and Multi-Factorial Theories.Journal of Alzheimer's disease : JAD · 2024Article
- Faster decline of very prodromal dementia with Lewy bodies when amyloid positive.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Dysregulation of cerebral perfusion dynamics is associated with Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review examined the longitudinal association between amyloid-β (Aβ) accumulation and cognitive decline in cognitively healthy adults. It was conducted using the PubMed, Embase, PsycInfo, and Web of Science databases. The methodological quality of the selected articles was assessed. In fine, seventeen longitudinal clinical studies were included in this review. A minority (seven out of 17) of studies reported a statistically significant association or prediction of cognitive decline with Aβ change, measured by positron emission tomography (PET; n = 6) and lumbar puncture (n = 1), with a mean follow-up duration of 3.17 years for cognition and 2.99 years for Aβ. The studies reporting significant results with PET found differences in the frontal, posterior cingular, lateral parietal and global (whole brain) cortices as well as in the precuneus. Significant associations were found with episodic memory (n = 6) and global cognition (n = 1). Five of the seven studies using a composite cognitive score found significant results. A quality assessment revealed widespread methodological biases, such as failure to report or account for loss-to follow up and missing data, and failure to report
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.