Evidence map›Paper›PMID 37179681›Full record

ArticleAnnals of Indian Academy of Neurology

Tuberculosis of the Spinal Cord.

Divyani Garg, Divya M Radhakrishnan, Umang Agrawal, Harshad Arvind Vanjare, Edmond Jonathan Gandham, Abi Manesh

Open access · diamondAbstract read
In one paragraph

Article in Annals of Indian Academy of Neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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  10. Article
  11. [Pott's disease, surgical case series and literature review].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Review
  12. [First SADI-S in the Mexican Institute of Social Security].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Divyani GargDepartment of Neurology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
Divya M RadhakrishnanDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Umang AgrawalDepartment of Infectious Diseases, PD Hinduja Hospital and MRC, Mumbai, Maharashtra, India.
Harshad Arvind VanjareDepartment of Radiodiagnosis, Christian Medical College, Vellore, Tamil Nadu, India.
Edmond Jonathan GandhamDepartment of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.
Abi ManeshDepartment of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
Vardhman Mahavir Medical College & Safdarjung Hospital · INAll India Institute of Medical Sciences · INChristian Medical College & Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis involving the spinal cord is associated with high mortality and disabling long-term sequelae. Although tuberculous radiculomyelitis is the most frequent complication, pleomorphic clinical manifestations exist. Diagnosis can be challenging among patients with isolated spinal cord tuberculosis due to diverse clinical and radiological presentations. The principles of management of tuberculosis of the spinal cord are primarily derived from, and dependent upon, trials on tuberculous meningitis (TBM). Although facilitating mycobacterial killing and controlling host inflammatory response within the nervous system remain the primary objectives, several unique features require attention. The paradoxical worsening is more frequent, often with devastating outcomes. The role of anti-inflammatory agents such as steroids in adhesive tuberculous radiculomyelitis remains unclear. Surgical interventions may benefit a small proportion of patients with spinal cord tuberculosis. Currently, the evidence base in the management of spinal cord tuberculosis is limited to uncontrolled small-scale data. Despite the gargantuan burden of tuberculosis, particularly in lower and middle-income countries, large-scale cohesive data are surprisingly sparse. In this review, we highlight the varied clinical and radiological presentations, performance of various diagnostic modalities, summarize data on the efficacy of treatment options, and propose a way forward to improve outcomes in these patients.

Indexed as

Abscessarachnoiditismycobacteriamyelopathysyrinxtuberculosis

Identifiers

PMID37179681
PMCPMC10171010
OpenAlexW4312460557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.