Evidence map›Paper›PMID 37178307›Full record

ArticleApplied microbiology and biotechnology2023

Adaptive responses of yeast strains tolerant to acidic pH, acetate, and supraoptimal temperature.

Prisciluis Caheri Salas-Navarrete, Paul Rosas-Santiago, Ramón Suárez-Rodríguez, Alfredo Martínez, Luis Caspeta

Open access · hybridAbstract read
In one paragraph

Article in Applied microbiology and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. ZnFood chemistry. Molecular sciences · 2025
    Article
  5. The regulatory network ofMicrobiology spectrum · 2025
    Article
  6. Acidic pH Reduces Fluconazole Susceptibility inJournal of microbiology and biotechnology · 2025
    Article
  7. Review
  8. Article
  9. Applied and environmental microbiology · 2024
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Prisciluis Caheri Salas-NavarreteCentro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca, 62209, Morelos, México.
Paul Rosas-SantiagoDepartamento de Biología Molecular de Plantas, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa, Cuernavaca, 62210, Morelos, México.
Ramón Suárez-RodríguezCentro de Investigación en Biotecnología, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca, 62209, Morelos, México.
Alfredo MartínezDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa, Cuernavaca, 62210, Morelos, México.
Luis CaspetaDepartamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Col. Chamilpa, Cuernavaca, 62210, Morelos, México. luis.caspeta@ibt.unam.mx.ORCID http://orcid.org/0000-0003-4622-5179
Universidad Autónoma del Estado de Morelos · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ethanol fermentations can be prematurely halted as Saccharomyces cerevisiae faces adverse conditions, such as acidic pH, presence of acetic acid, and supraoptimal temperatures. The knowledge on yeast responses to these conditions is essential to endowing a tolerant phenotype to another strain by targeted genetic manipulation. In this study, physiological and whole-genome analyses were conducted to obtain insights on molecular responses which potentially render yeast tolerant towards thermoacidic conditions. To this end, we used thermotolerant TTY23, acid tolerant AT22, and thermo-acid tolerant TAT12 strains previously generated by adaptive laboratory evolution (ALE) experiments. The results showed an increase in thermoacidic profiles in the tolerant strains. The whole-genome sequence revealed the importance of genes related to: H

Indexed as

Saccharomyces cerevisiae ProteinsVacuolar Proton-Translocating ATPasesAcetic AcidGlucoseHydrogen-Ion ConcentrationMembrane ProteinsProtein Phosphatase 1Saccharomyces cerevisiaeTemperatureTrans-ActivatorsAcetic AcidATO2 protein, S cerevisiaeBAS1 protein, S cerevisiaeGlucoseMembrane ProteinsProtein Phosphatase 1REG1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsTrans-ActivatorsVacuolar Proton-Translocating ATPasesVMA2 protein, S cerevisiaeAdaptive cellular responsesAdaptive laboratory evolutionGenome-scale analysisSaccharomyces cerevisiaeThermo-acidic tolerance

Identifiers

PMID37178307
PMCPMC10238323
OpenAlexW4376598279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.